MSLN-UVRAG Fusion FISH Probe
The MSLN-UVRAG Fusion FISH Probe is used to confirm a fusion of the MSLN and UVRAG genes. The fusion of the MSLN and UVRAG genes has been associated with Mesothelioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MSLN-UVRAG-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| MSLN-UVRAG-20-RERE | 20 (40 μL) | 200 μL |
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| MSLN-UVRAG-20-REOR | 20 (40 μL) | 200 μL |
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| MSLN-UVRAG-20-REGO | 20 (40 μL) | 200 μL |
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| MSLN-UVRAG-20-REGR | 20 (40 μL) | 200 μL |
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| MSLN-UVRAG-20-REAQ | 20 (40 μL) | 200 μL |
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| MSLN-UVRAG-20-ORRE | 20 (40 μL) | 200 μL |
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| MSLN-UVRAG-20-OROR | 20 (40 μL) | 200 μL |
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| MSLN-UVRAG-20-ORGO | 20 (40 μL) | 200 μL |
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| MSLN-UVRAG-20-ORAQ | 20 (40 μL) | 200 μL |
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| MSLN-UVRAG-20-GORE | 20 (40 μL) | 200 μL |
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| MSLN-UVRAG-20-GOOR | 20 (40 μL) | 200 μL |
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| MSLN-UVRAG-20-GOGO | 20 (40 μL) | 200 μL |
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| MSLN-UVRAG-20-GOGR | 20 (40 μL) | 200 μL |
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| MSLN-UVRAG-20-GOAQ | 20 (40 μL) | 200 μL |
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| MSLN-UVRAG-20-GRRE | 20 (40 μL) | 200 μL |
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| MSLN-UVRAG-20-GROR | 20 (40 μL) | 200 μL |
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| MSLN-UVRAG-20-GRGO | 20 (40 μL) | 200 μL |
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| MSLN-UVRAG-20-GRGR | 20 (40 μL) | 200 μL |
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| MSLN-UVRAG-20-GRAQ | 20 (40 μL) | 200 μL |
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| MSLN-UVRAG-20-AQRE | 20 (40 μL) | 200 μL |
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| MSLN-UVRAG-20-AQOR | 20 (40 μL) | 200 μL |
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| MSLN-UVRAG-20-AQGO | 20 (40 μL) | 200 μL |
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| MSLN-UVRAG-20-AQGR | 20 (40 μL) | 200 μL |
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| MSLN-UVRAG-20-AQAQ | 20 (40 μL) | 200 μL |
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UVRAG Gene Summary
This gene complements the ultraviolet sensitivity of xeroderma pigmentosum group C cells and encodes a protein with a C2 domain. The protein activates the Beclin1-PI(3)KC3 complex, promoting autophagy and suppressing the proliferation and tumorigenicity of human colon cancer cells. Chromosomal aberrations involving this gene are associated with left-right axis malformation and mutations in this gene have been associated with colon cancer. [provided by RefSeq, Jul 2008]
Gene Name: UV Radiation Resistance Associated
Chromosome: CHR11: 75526211 -75855282
Locus: 11q13.5
MSLN Gene Summary
This gene encodes a preproprotein that is proteolytically processed to generate two protein products, megakaryocyte potentiating factor and mesothelin. Megakaryocyte potentiating factor functions as a cytokine that can stimulate colony formation of bone marrow megakaryocytes. Mesothelin is a glycosylphosphatidylinositol-anchored cell-surface protein that may function as a cell adhesion protein. This protein is overexpressed in epithelial mesotheliomas, ovarian cancers and in specific squamous cell carcinomas. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016]
Gene Name: Mesothelin
Chromosome: CHR16: 810764 -818865
Locus: 16p13.3
Gene Diseases
The MSLN UVRAG Fusion has been associated with the following diseases:
| Disease Name |
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| Mesothelioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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