MTA1-PACS2 Fusion FISH Probe
The MTA1-PACS2 Fusion FISH Probe is used to confirm a fusion of the MTA1 and PACS2 genes. The fusion of the MTA1 and PACS2 genes has been associated with Lung Squamous Cell Carcinoma, and Head And Neck Squamous Cell Carcinoma . These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MTA1-PACS2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| MTA1-PACS2-20-RERE | 20 (40 μL) | 200 μL |
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| MTA1-PACS2-20-REOR | 20 (40 μL) | 200 μL |
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| MTA1-PACS2-20-REGO | 20 (40 μL) | 200 μL |
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| MTA1-PACS2-20-REGR | 20 (40 μL) | 200 μL |
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| MTA1-PACS2-20-REAQ | 20 (40 μL) | 200 μL |
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| MTA1-PACS2-20-ORRE | 20 (40 μL) | 200 μL |
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| MTA1-PACS2-20-OROR | 20 (40 μL) | 200 μL |
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| MTA1-PACS2-20-ORGO | 20 (40 μL) | 200 μL |
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| MTA1-PACS2-20-ORAQ | 20 (40 μL) | 200 μL |
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| MTA1-PACS2-20-GORE | 20 (40 μL) | 200 μL |
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| MTA1-PACS2-20-GOOR | 20 (40 μL) | 200 μL |
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| MTA1-PACS2-20-GOGO | 20 (40 μL) | 200 μL |
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| MTA1-PACS2-20-GOGR | 20 (40 μL) | 200 μL |
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| MTA1-PACS2-20-GOAQ | 20 (40 μL) | 200 μL |
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| MTA1-PACS2-20-GRRE | 20 (40 μL) | 200 μL |
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| MTA1-PACS2-20-GROR | 20 (40 μL) | 200 μL |
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| MTA1-PACS2-20-GRGO | 20 (40 μL) | 200 μL |
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| MTA1-PACS2-20-GRGR | 20 (40 μL) | 200 μL |
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| MTA1-PACS2-20-GRAQ | 20 (40 μL) | 200 μL |
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| MTA1-PACS2-20-AQRE | 20 (40 μL) | 200 μL |
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| MTA1-PACS2-20-AQOR | 20 (40 μL) | 200 μL |
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| MTA1-PACS2-20-AQGO | 20 (40 μL) | 200 μL |
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| MTA1-PACS2-20-AQGR | 20 (40 μL) | 200 μL |
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| MTA1-PACS2-20-AQAQ | 20 (40 μL) | 200 μL |
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MTA1 Gene Summary
This gene encodes a protein that was identified in a screen for genes expressed in metastatic cells, specifically, mammary adenocarcinoma cell lines. Expression of this gene has been correlated with the metastatic potential of at least two types of carcinomas although it is also expressed in many normal tissues. The role it plays in metastasis is unclear. It was initially thought to be the 70kD component of a nucleosome remodeling deacetylase complex, NuRD, but it is more likely that this component is a different but very similar protein. These two proteins are so closely related, though, that they share the same types of domains. These domains include two DNA binding domains, a dimerization domain, and a domain commonly found in proteins that methylate DNA. The profile and activity of this gene product suggest that it is involved in regulating transcription and that this may be accomplished by chromatin remodeling. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]
Gene Name: Metastasis Associated 1
Chromosome: CHR14: 105886185 -105937057
Locus: 14q32.33
PACS2 Gene Summary
The Phosphofurin Acidic Cluster Sorting Protein 2 (PACS2) gene is located on chr14 :105767169-105864484 at 14q32.33.
Gene Name: Phosphofurin Acidic Cluster Sorting Protein 2
Chromosome: CHR14: 105767169 -105864484
Locus: 14q32.33
Gene Diseases
The MTA1 PACS2 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
| Head And Neck Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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