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MTA2-CDHR5 Fusion FISH Probe

The MTA2-CDHR5 Fusion FISH Probe is used to confirm a fusion of the MTA2 and CDHR5 genes. The fusion of the MTA2 and CDHR5 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
MTA2-CDHR5-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
MTA2-CDHR5-20-RERE 20 (40 μL) 200 μL
MTA2-CDHR5-20-REOR 20 (40 μL) 200 μL
MTA2-CDHR5-20-REGO 20 (40 μL) 200 μL
MTA2-CDHR5-20-REGR 20 (40 μL) 200 μL
MTA2-CDHR5-20-REAQ 20 (40 μL) 200 μL
MTA2-CDHR5-20-ORRE 20 (40 μL) 200 μL
MTA2-CDHR5-20-OROR 20 (40 μL) 200 μL
MTA2-CDHR5-20-ORGO 20 (40 μL) 200 μL
MTA2-CDHR5-20-ORAQ 20 (40 μL) 200 μL
MTA2-CDHR5-20-GORE 20 (40 μL) 200 μL
MTA2-CDHR5-20-GOOR 20 (40 μL) 200 μL
MTA2-CDHR5-20-GOGO 20 (40 μL) 200 μL
MTA2-CDHR5-20-GOGR 20 (40 μL) 200 μL
MTA2-CDHR5-20-GOAQ 20 (40 μL) 200 μL
MTA2-CDHR5-20-GRRE 20 (40 μL) 200 μL
MTA2-CDHR5-20-GROR 20 (40 μL) 200 μL
MTA2-CDHR5-20-GRGO 20 (40 μL) 200 μL
MTA2-CDHR5-20-GRGR 20 (40 μL) 200 μL
MTA2-CDHR5-20-GRAQ 20 (40 μL) 200 μL
MTA2-CDHR5-20-AQRE 20 (40 μL) 200 μL
MTA2-CDHR5-20-AQOR 20 (40 μL) 200 μL
MTA2-CDHR5-20-AQGO 20 (40 μL) 200 μL
MTA2-CDHR5-20-AQGR 20 (40 μL) 200 μL
MTA2-CDHR5-20-AQAQ 20 (40 μL) 200 μL

MTA2 Gene Summary

This gene encodes a protein that has been identified as a component of NuRD, a nucleosome remodeling deacetylase complex identified in the nucleus of human cells. It shows a very broad expression pattern and is strongly expressed in many tissues. It may represent one member of a small gene family that encode different but related proteins involved either directly or indirectly in transcriptional regulation. Their indirect effects on transcriptional regulation may include chromatin remodeling. It is closely related to another member of this family, a protein that has been correlated with the metastatic potential of certain carcinomas. These two proteins are so closely related that they share the same types of domains. These domains include two DNA binding domains, a dimerization domain, and a domain commonly found in proteins that methylate DNA. One of the proteins known to be a target protein for this gene product is p53. Deacetylation of p53 is correlated with a loss of growth inhibition in transformed cells supporting a connection between these gene family members and metastasis. [provided by RefSeq, May 2011]

Gene Name: Metastasis Associated 1 Family Member 2

Chromosome: CHR11: 62360674 -62369312

Locus: 11q12.3

CDHR5 Gene Summary

This gene is a novel mucin-like gene that is a member of the cadherin superfamily. While encoding nonpolymorphic tandem repeats rich in proline, serine and threonine similar to mucin proteins, the gene also contains sequence encoding calcium-binding motifs found in all cadherins. The role of the hybrid extracellular region and the specific function of this protein have not yet been determined. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jan 2010]

Gene Name: Cadherin Related Family Member 5

Chromosome: CHR11: 616564 -625067

Locus: 11p15.5

Gene Diseases

The MTA2 CDHR5 Fusion has been associated with the following diseases:

Disease Name
Breast Invasive Carcinoma

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this probe.