MTCH2-FHIT Fusion FISH Probe
The MTCH2-FHIT Fusion FISH Probe is used to confirm a fusion of the MTCH2 and FHIT genes. The fusion of the MTCH2 and FHIT genes has been associated with Ovarian Serous Cystadenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MTCH2-FHIT-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| MTCH2-FHIT-20-RERE | 20 (40 μL) | 200 μL |
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| MTCH2-FHIT-20-REOR | 20 (40 μL) | 200 μL |
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| MTCH2-FHIT-20-REGO | 20 (40 μL) | 200 μL |
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| MTCH2-FHIT-20-REGR | 20 (40 μL) | 200 μL |
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| MTCH2-FHIT-20-REAQ | 20 (40 μL) | 200 μL |
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| MTCH2-FHIT-20-ORRE | 20 (40 μL) | 200 μL |
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| MTCH2-FHIT-20-OROR | 20 (40 μL) | 200 μL |
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| MTCH2-FHIT-20-ORGO | 20 (40 μL) | 200 μL |
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| MTCH2-FHIT-20-ORAQ | 20 (40 μL) | 200 μL |
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| MTCH2-FHIT-20-GORE | 20 (40 μL) | 200 μL |
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| MTCH2-FHIT-20-GOOR | 20 (40 μL) | 200 μL |
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| MTCH2-FHIT-20-GOGO | 20 (40 μL) | 200 μL |
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| MTCH2-FHIT-20-GOGR | 20 (40 μL) | 200 μL |
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| MTCH2-FHIT-20-GOAQ | 20 (40 μL) | 200 μL |
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| MTCH2-FHIT-20-GRRE | 20 (40 μL) | 200 μL |
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| MTCH2-FHIT-20-GROR | 20 (40 μL) | 200 μL |
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| MTCH2-FHIT-20-GRGO | 20 (40 μL) | 200 μL |
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| MTCH2-FHIT-20-GRGR | 20 (40 μL) | 200 μL |
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| MTCH2-FHIT-20-GRAQ | 20 (40 μL) | 200 μL |
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| MTCH2-FHIT-20-AQRE | 20 (40 μL) | 200 μL |
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| MTCH2-FHIT-20-AQOR | 20 (40 μL) | 200 μL |
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| MTCH2-FHIT-20-AQGO | 20 (40 μL) | 200 μL |
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| MTCH2-FHIT-20-AQGR | 20 (40 μL) | 200 μL |
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| MTCH2-FHIT-20-AQAQ | 20 (40 μL) | 200 μL |
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FHIT Gene Summary
The protein encoded by this gene is a P1-P3-bis(5'-adenosyl) triphosphate hydrolase involved in purine metabolism. This gene encompasses the common fragile site FRA3B on chromosome 3, where carcinogen-induced damage can lead to translocations and aberrant transcripts. In fact, aberrant transcripts from this gene have been found in about half of all esophageal, stomach, and colon carcinomas. The encoded protein is also a tumor suppressor, as loss of its activity results in replication stress and DNA damage. [provided by RefSeq, Aug 2017]
Gene Name: Fragile Histidine Triad
Chromosome: CHR3: 59735035 -61237133
Locus: 3p14.2
MTCH2 Gene Summary
This gene encodes a member of the SLC25 family of nuclear-encoded transporters that are localized in the inner mitochondrial membrane. Members of this superfamily are involved in many metabolic pathways and cell functions. Genome-wide association studies in human have identified single-nucleotide polymorphisms in several loci associated with obesity. This gene is one such locus, which is highly expressed in white adipose tissue and adipocytes, and thought to play a regulatory role in adipocyte differentiation and biology. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. A recent study showed this gene to be an authentic stop codon readthrough target that can produce two isoforms from the same mRNA by use of alternative in-frame translation termination codons. [provided by RefSeq, Dec 2017]
Gene Name: Mitochondrial Carrier 2
Chromosome: CHR11: 47638857 -47664206
Locus: 11p11.2
Gene Diseases
The MTCH2 FHIT Fusion has been associated with the following diseases:
| Disease Name |
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| Ovarian Serous Cystadenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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