MTHFD1L-RGS17 Fusion FISH Probe
The MTHFD1L-RGS17 Fusion FISH Probe is used to confirm a fusion of the MTHFD1L and RGS17 genes. The fusion of the MTHFD1L and RGS17 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MTHFD1L-RGS17-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| MTHFD1L-RGS17-20-RERE | 20 (40 μL) | 200 μL |
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| MTHFD1L-RGS17-20-REOR | 20 (40 μL) | 200 μL |
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| MTHFD1L-RGS17-20-REGO | 20 (40 μL) | 200 μL |
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| MTHFD1L-RGS17-20-REGR | 20 (40 μL) | 200 μL |
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| MTHFD1L-RGS17-20-REAQ | 20 (40 μL) | 200 μL |
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| MTHFD1L-RGS17-20-ORRE | 20 (40 μL) | 200 μL |
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| MTHFD1L-RGS17-20-OROR | 20 (40 μL) | 200 μL |
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| MTHFD1L-RGS17-20-ORGO | 20 (40 μL) | 200 μL |
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| MTHFD1L-RGS17-20-ORAQ | 20 (40 μL) | 200 μL |
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| MTHFD1L-RGS17-20-GORE | 20 (40 μL) | 200 μL |
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| MTHFD1L-RGS17-20-GOOR | 20 (40 μL) | 200 μL |
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| MTHFD1L-RGS17-20-GOGO | 20 (40 μL) | 200 μL |
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| MTHFD1L-RGS17-20-GOGR | 20 (40 μL) | 200 μL |
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| MTHFD1L-RGS17-20-GOAQ | 20 (40 μL) | 200 μL |
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| MTHFD1L-RGS17-20-GRRE | 20 (40 μL) | 200 μL |
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| MTHFD1L-RGS17-20-GROR | 20 (40 μL) | 200 μL |
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| MTHFD1L-RGS17-20-GRGO | 20 (40 μL) | 200 μL |
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| MTHFD1L-RGS17-20-GRGR | 20 (40 μL) | 200 μL |
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| MTHFD1L-RGS17-20-GRAQ | 20 (40 μL) | 200 μL |
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| MTHFD1L-RGS17-20-AQRE | 20 (40 μL) | 200 μL |
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| MTHFD1L-RGS17-20-AQOR | 20 (40 μL) | 200 μL |
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| MTHFD1L-RGS17-20-AQGO | 20 (40 μL) | 200 μL |
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| MTHFD1L-RGS17-20-AQGR | 20 (40 μL) | 200 μL |
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| MTHFD1L-RGS17-20-AQAQ | 20 (40 μL) | 200 μL |
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MTHFD1L Gene Summary
The protein encoded by this gene is involved in the synthesis of tetrahydrofolate (THF) in the mitochondrion. THF is important in the de novo synthesis of purines and thymidylate and in the regeneration of methionine from homocysteine. Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jun 2011]
Gene Name: Methylenetetrahydrofolate Dehydrogenase (NADP+ Dependent) 1 Like
Chromosome: CHR6: 151186814 -151423023
Locus: 6q25.1
RGS17 Gene Summary
This gene encodes a member of the regulator of G-protein signaling family. This protein contains a conserved, 120 amino acid motif called the RGS domain and a cysteine-rich region. The protein attenuates the signaling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. [provided by RefSeq, Jul 2008]
Gene Name: Regulator Of G Protein Signaling 17
Chromosome: CHR6: 153332031 -153452389
Locus: 6q25.2
Gene Diseases
The MTHFD1L RGS17 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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