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MUC1-PKLR Fusion FISH Probe

The MUC1-PKLR Fusion FISH Probe is used to confirm a fusion of the MUC1 and PKLR genes. The fusion of the MUC1 and PKLR genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
MUC1-PKLR-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
MUC1-PKLR-20-RERE 20 (40 μL) 200 μL
MUC1-PKLR-20-REOR 20 (40 μL) 200 μL
MUC1-PKLR-20-REGO 20 (40 μL) 200 μL
MUC1-PKLR-20-REGR 20 (40 μL) 200 μL
MUC1-PKLR-20-REAQ 20 (40 μL) 200 μL
MUC1-PKLR-20-ORRE 20 (40 μL) 200 μL
MUC1-PKLR-20-OROR 20 (40 μL) 200 μL
MUC1-PKLR-20-ORGO 20 (40 μL) 200 μL
MUC1-PKLR-20-ORAQ 20 (40 μL) 200 μL
MUC1-PKLR-20-GORE 20 (40 μL) 200 μL
MUC1-PKLR-20-GOOR 20 (40 μL) 200 μL
MUC1-PKLR-20-GOGO 20 (40 μL) 200 μL
MUC1-PKLR-20-GOGR 20 (40 μL) 200 μL
MUC1-PKLR-20-GOAQ 20 (40 μL) 200 μL
MUC1-PKLR-20-GRRE 20 (40 μL) 200 μL
MUC1-PKLR-20-GROR 20 (40 μL) 200 μL
MUC1-PKLR-20-GRGO 20 (40 μL) 200 μL
MUC1-PKLR-20-GRGR 20 (40 μL) 200 μL
MUC1-PKLR-20-GRAQ 20 (40 μL) 200 μL
MUC1-PKLR-20-AQRE 20 (40 μL) 200 μL
MUC1-PKLR-20-AQOR 20 (40 μL) 200 μL
MUC1-PKLR-20-AQGO 20 (40 μL) 200 μL
MUC1-PKLR-20-AQGR 20 (40 μL) 200 μL
MUC1-PKLR-20-AQAQ 20 (40 μL) 200 μL

MUC1 Gene Summary

This gene encodes a membrane-bound protein that is a member of the mucin family. Mucins are O-glycosylated proteins that play an essential role in forming protective mucous barriers on epithelial surfaces. These proteins also play a role in intracellular signaling. This protein is expressed on the apical surface of epithelial cells that line the mucosal surfaces of many different tissues including lung, breast stomach and pancreas. This protein is proteolytically cleaved into alpha and beta subunits that form a heterodimeric complex. The N-terminal alpha subunit functions in cell-adhesion and the C-terminal beta subunit is involved in cell signaling. Overexpression, aberrant intracellular localization, and changes in glycosylation of this protein have been associated with carcinomas. This gene is known to contain a highly polymorphic variable number tandem repeats (VNTR) domain. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Feb 2011]

Gene Name: Mucin 1, Cell Surface Associated

Chromosome: CHR1: 155158299 -155162706

Locus: 1q22

PKLR Gene Summary

The protein encoded by this gene is a pyruvate kinase that catalyzes the transphosphorylation of phohsphoenolpyruvate into pyruvate and ATP, which is the rate-limiting step of glycolysis. Defects in this enzyme, due to gene mutations or genetic variations, are the common cause of chronic hereditary nonspherocytic hemolytic anemia (CNSHA or HNSHA). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Name: Pyruvate Kinase L/R

Chromosome: CHR1: 155259083 -155271225

Locus: 1q22

Gene Diseases

The MUC1 PKLR Fusion has been associated with the following diseases:

Disease Name
Lung Adenocarcinoma

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this probe.