MXI1-ADD3 Fusion FISH Probe
The MXI1-ADD3 Fusion FISH Probe is used to confirm a fusion of the MXI1 and ADD3 genes. The fusion of the MXI1 and ADD3 genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| MXI1-ADD3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
|
|
| MXI1-ADD3-20-RERE | 20 (40 μL) | 200 μL |
|
|
| MXI1-ADD3-20-REOR | 20 (40 μL) | 200 μL |
|
|
| MXI1-ADD3-20-REGO | 20 (40 μL) | 200 μL |
|
|
| MXI1-ADD3-20-REGR | 20 (40 μL) | 200 μL |
|
|
| MXI1-ADD3-20-REAQ | 20 (40 μL) | 200 μL |
|
|
| MXI1-ADD3-20-ORRE | 20 (40 μL) | 200 μL |
|
|
| MXI1-ADD3-20-OROR | 20 (40 μL) | 200 μL |
|
|
| MXI1-ADD3-20-ORGO | 20 (40 μL) | 200 μL |
|
|
| MXI1-ADD3-20-ORAQ | 20 (40 μL) | 200 μL |
|
|
| MXI1-ADD3-20-GORE | 20 (40 μL) | 200 μL |
|
|
| MXI1-ADD3-20-GOOR | 20 (40 μL) | 200 μL |
|
|
| MXI1-ADD3-20-GOGO | 20 (40 μL) | 200 μL |
|
|
| MXI1-ADD3-20-GOGR | 20 (40 μL) | 200 μL |
|
|
| MXI1-ADD3-20-GOAQ | 20 (40 μL) | 200 μL |
|
|
| MXI1-ADD3-20-GRRE | 20 (40 μL) | 200 μL |
|
|
| MXI1-ADD3-20-GROR | 20 (40 μL) | 200 μL |
|
|
| MXI1-ADD3-20-GRGO | 20 (40 μL) | 200 μL |
|
|
| MXI1-ADD3-20-GRGR | 20 (40 μL) | 200 μL |
|
|
| MXI1-ADD3-20-GRAQ | 20 (40 μL) | 200 μL |
|
|
| MXI1-ADD3-20-AQRE | 20 (40 μL) | 200 μL |
|
|
| MXI1-ADD3-20-AQOR | 20 (40 μL) | 200 μL |
|
|
| MXI1-ADD3-20-AQGO | 20 (40 μL) | 200 μL |
|
|
| MXI1-ADD3-20-AQGR | 20 (40 μL) | 200 μL |
|
|
| MXI1-ADD3-20-AQAQ | 20 (40 μL) | 200 μL |
|
ADD3 Gene Summary
Adducins are heteromeric proteins composed of different subunits referred to as adducin alpha, beta and gamma. The three subunits are encoded by distinct genes and belong to a family of membrane skeletal proteins involved in the assembly of spectrin-actin network in erythrocytes and at sites of cell-cell contact in epithelial tissues. While adducins alpha and gamma are ubiquitously expressed, the expression of adducin beta is restricted to brain and hematopoietic tissues. Adducin, originally purified from human erythrocytes, was found to be a heterodimer of adducins alpha and beta. Polymorphisms resulting in amino acid substitutions in these two subunits have been associated with the regulation of blood pressure in an animal model of hypertension. Heterodimers consisting of alpha and gamma subunits have also been described. Structurally, each subunit is comprised of two distinct domains. The amino-terminal region is protease resistant and globular in shape, while the carboxy-terminal region is protease sensitive. The latter contains multiple phosphorylation sites for protein kinase C, the binding site for calmodulin, and is required for association with spectrin and actin. Alternatively spliced adducin gamma transcripts encoding different isoforms have been described. The functions of the different isoforms are not known. [provided by RefSeq, Jul 2008]
Gene Name: Adducin 3
Chromosome: CHR10: 111765725 -111895323
Locus: 10q25.1-q25.2
MXI1 Gene Summary
Expression of the c-myc gene, which produces an oncogenic transcription factor, is tightly regulated in normal cells but is frequently deregulated in human cancers. The protein encoded by this gene is a transcriptional repressor thought to negatively regulate MYC function, and is therefore a potential tumor suppressor. This protein inhibits the transcriptional activity of MYC by competing for MAX, another basic helix-loop-helix protein that binds to MYC and is required for its function. Defects in this gene are frequently found in patients with prostate tumors. Three alternatively spliced transcripts encoding different isoforms have been described. Additional alternatively spliced transcripts may exist but the products of these transcripts have not been verified experimentally. [provided by RefSeq, Jul 2008]
Gene Name: MAX Interactor 1, Dimerization Protein
Chromosome: CHR10: 111967362 -112047123
Locus: 10q25.2
Gene Diseases
The MXI1 ADD3 Fusion has been associated with the following diseases:
| Disease Name |
|---|
| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|