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NBN-RIPK2 Fusion FISH Probe

The NBN-RIPK2 Fusion FISH Probe is used to confirm a fusion of the NBN and RIPK2 genes. The fusion of the NBN and RIPK2 genes has been associated with Bladder Urothelial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
NBN-RIPK2-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
NBN-RIPK2-20-RERE 20 (40 μL) 200 μL
NBN-RIPK2-20-REOR 20 (40 μL) 200 μL
NBN-RIPK2-20-REGO 20 (40 μL) 200 μL
NBN-RIPK2-20-REGR 20 (40 μL) 200 μL
NBN-RIPK2-20-REAQ 20 (40 μL) 200 μL
NBN-RIPK2-20-ORRE 20 (40 μL) 200 μL
NBN-RIPK2-20-OROR 20 (40 μL) 200 μL
NBN-RIPK2-20-ORGO 20 (40 μL) 200 μL
NBN-RIPK2-20-ORAQ 20 (40 μL) 200 μL
NBN-RIPK2-20-GORE 20 (40 μL) 200 μL
NBN-RIPK2-20-GOOR 20 (40 μL) 200 μL
NBN-RIPK2-20-GOGO 20 (40 μL) 200 μL
NBN-RIPK2-20-GOGR 20 (40 μL) 200 μL
NBN-RIPK2-20-GOAQ 20 (40 μL) 200 μL
NBN-RIPK2-20-GRRE 20 (40 μL) 200 μL
NBN-RIPK2-20-GROR 20 (40 μL) 200 μL
NBN-RIPK2-20-GRGO 20 (40 μL) 200 μL
NBN-RIPK2-20-GRGR 20 (40 μL) 200 μL
NBN-RIPK2-20-GRAQ 20 (40 μL) 200 μL
NBN-RIPK2-20-AQRE 20 (40 μL) 200 μL
NBN-RIPK2-20-AQOR 20 (40 μL) 200 μL
NBN-RIPK2-20-AQGO 20 (40 μL) 200 μL
NBN-RIPK2-20-AQGR 20 (40 μL) 200 μL
NBN-RIPK2-20-AQAQ 20 (40 μL) 200 μL

NBN Gene Summary

Mutations in this gene are associated with Nijmegen breakage syndrome, an autosomal recessive chromosomal instability syndrome characterized by microcephaly, growth retardation, immunodeficiency, and cancer predisposition. The encoded protein is a member of the MRE11/RAD50 double-strand break repair complex which consists of 5 proteins. This gene product is thought to be involved in DNA double-strand break repair and DNA damage-induced checkpoint activation. [provided by RefSeq, Jul 2008]

Gene Name: Nibrin

Chromosome: CHR8: 90945563 -90996899

Locus: 8q21.3

RIPK2 Gene Summary

This gene encodes a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases. The encoded protein contains a C-terminal caspase activation and recruitment domain (CARD), and is a component of signaling complexes in both the innate and adaptive immune pathways. It is a potent activator of NF-kappaB and inducer of apoptosis in response to various stimuli. [provided by RefSeq, Jul 2008]

Gene Name: Receptor Interacting Serine/threonine Kinase 2

Chromosome: CHR8: 90769974 -90803292

Locus: 8q21.3

Gene Diseases

The NBN RIPK2 Fusion has been associated with the following diseases:

Disease Name
Bladder Urothelial Carcinoma

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this probe.