NCK1-PCCB Fusion FISH Probe
The NCK1-PCCB Fusion FISH Probe is used to confirm a fusion of the NCK1 and PCCB genes. The fusion of the NCK1 and PCCB genes has been associated with Bladder Urothelial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| NCK1-PCCB-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| NCK1-PCCB-20-RERE | 20 (40 μL) | 200 μL |
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| NCK1-PCCB-20-REOR | 20 (40 μL) | 200 μL |
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| NCK1-PCCB-20-REGO | 20 (40 μL) | 200 μL |
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| NCK1-PCCB-20-REGR | 20 (40 μL) | 200 μL |
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| NCK1-PCCB-20-REAQ | 20 (40 μL) | 200 μL |
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| NCK1-PCCB-20-ORRE | 20 (40 μL) | 200 μL |
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| NCK1-PCCB-20-OROR | 20 (40 μL) | 200 μL |
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| NCK1-PCCB-20-ORGO | 20 (40 μL) | 200 μL |
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| NCK1-PCCB-20-ORAQ | 20 (40 μL) | 200 μL |
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| NCK1-PCCB-20-GORE | 20 (40 μL) | 200 μL |
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| NCK1-PCCB-20-GOOR | 20 (40 μL) | 200 μL |
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| NCK1-PCCB-20-GOGO | 20 (40 μL) | 200 μL |
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| NCK1-PCCB-20-GOGR | 20 (40 μL) | 200 μL |
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| NCK1-PCCB-20-GOAQ | 20 (40 μL) | 200 μL |
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| NCK1-PCCB-20-GRRE | 20 (40 μL) | 200 μL |
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| NCK1-PCCB-20-GROR | 20 (40 μL) | 200 μL |
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| NCK1-PCCB-20-GRGO | 20 (40 μL) | 200 μL |
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| NCK1-PCCB-20-GRGR | 20 (40 μL) | 200 μL |
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| NCK1-PCCB-20-GRAQ | 20 (40 μL) | 200 μL |
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| NCK1-PCCB-20-AQRE | 20 (40 μL) | 200 μL |
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| NCK1-PCCB-20-AQOR | 20 (40 μL) | 200 μL |
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| NCK1-PCCB-20-AQGO | 20 (40 μL) | 200 μL |
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| NCK1-PCCB-20-AQGR | 20 (40 μL) | 200 μL |
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| NCK1-PCCB-20-AQAQ | 20 (40 μL) | 200 μL |
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NCK1 Gene Summary
The protein encoded by this gene is one of the signaling and transforming proteins containing Src homology 2 and 3 (SH2 and SH3) domains. It is located in the cytoplasm and is an adaptor protein involved in transducing signals from receptor tyrosine kinases to downstream signal recipients such as RAS. Alternatively spliced transcript variants encoding different isoforms have been found. [provided by RefSeq, Jun 2010]
Gene Name: NCK Adaptor Protein 1
Chromosome: CHR3: 136581049 -136667968
Locus: 3q22.3
PCCB Gene Summary
The protein encoded by this gene is a subunit of the propionyl-CoA carboxylase (PCC) enzyme, which is involved in the catabolism of propionyl-CoA. PCC is a mitochondrial enzyme that probably acts as a dodecamer of six alpha subunits and six beta subunits. This gene encodes the beta subunit of PCC. Defects in this gene are a cause of propionic acidemia type II (PA-2). Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2010]
Gene Name: Propionyl-CoA Carboxylase Beta Subunit
Chromosome: CHR3: 135969166 -136049013
Locus: 3q22.3
Gene Diseases
The NCK1 PCCB Fusion has been associated with the following diseases:
| Disease Name |
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| Bladder Urothelial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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