NCL-STAT6 Fusion FISH Probe
The NCL-STAT6 Fusion FISH Probe is used to confirm a fusion of the NCL and STAT6 genes. The fusion of the NCL and STAT6 genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| NCL-STAT6-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| NCL-STAT6-20-RERE | 20 (40 μL) | 200 μL |
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| NCL-STAT6-20-REOR | 20 (40 μL) | 200 μL |
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| NCL-STAT6-20-REGO | 20 (40 μL) | 200 μL |
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| NCL-STAT6-20-REGR | 20 (40 μL) | 200 μL |
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| NCL-STAT6-20-REAQ | 20 (40 μL) | 200 μL |
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| NCL-STAT6-20-ORRE | 20 (40 μL) | 200 μL |
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| NCL-STAT6-20-OROR | 20 (40 μL) | 200 μL |
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| NCL-STAT6-20-ORGO | 20 (40 μL) | 200 μL |
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| NCL-STAT6-20-ORAQ | 20 (40 μL) | 200 μL |
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| NCL-STAT6-20-GORE | 20 (40 μL) | 200 μL |
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| NCL-STAT6-20-GOOR | 20 (40 μL) | 200 μL |
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| NCL-STAT6-20-GOGO | 20 (40 μL) | 200 μL |
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| NCL-STAT6-20-GOGR | 20 (40 μL) | 200 μL |
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| NCL-STAT6-20-GOAQ | 20 (40 μL) | 200 μL |
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| NCL-STAT6-20-GRRE | 20 (40 μL) | 200 μL |
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| NCL-STAT6-20-GROR | 20 (40 μL) | 200 μL |
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| NCL-STAT6-20-GRGO | 20 (40 μL) | 200 μL |
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| NCL-STAT6-20-GRGR | 20 (40 μL) | 200 μL |
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| NCL-STAT6-20-GRAQ | 20 (40 μL) | 200 μL |
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| NCL-STAT6-20-AQRE | 20 (40 μL) | 200 μL |
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| NCL-STAT6-20-AQOR | 20 (40 μL) | 200 μL |
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| NCL-STAT6-20-AQGO | 20 (40 μL) | 200 μL |
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| NCL-STAT6-20-AQGR | 20 (40 μL) | 200 μL |
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| NCL-STAT6-20-AQAQ | 20 (40 μL) | 200 μL |
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NCL Gene Summary
Nucleolin (NCL), a eukaryotic nucleolar phosphoprotein, is involved in the synthesis and maturation of ribosomes. It is located mainly in dense fibrillar regions of the nucleolus. Human NCL gene consists of 14 exons with 13 introns and spans approximately 11kb. The intron 11 of the NCL gene encodes a small nucleolar RNA, termed U20. [provided by RefSeq, Jul 2008]
Gene Name: Nucleolin
Chromosome: CHR2: 232319458 -232329205
Locus: 2q37.1
STAT6 Gene Summary
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]
Gene Name: Signal Transducer And Activator Of Transcription 6
Chromosome: CHR12: 57489186 -57505196
Locus: 12q13.3
Gene Diseases
The NCL STAT6 Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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