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NCOA2-EIF4EBP1 Fusion FISH Probe

The NCOA2-EIF4EBP1 Fusion FISH Probe is used to confirm a fusion of the NCOA2 and EIF4EBP1 genes. The fusion of the NCOA2 and EIF4EBP1 genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
NCOA2-EIF4EBP1-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
NCOA2-EIF4EBP1-20-RERE 20 (40 μL) 200 μL
NCOA2-EIF4EBP1-20-REOR 20 (40 μL) 200 μL
NCOA2-EIF4EBP1-20-REGO 20 (40 μL) 200 μL
NCOA2-EIF4EBP1-20-REGR 20 (40 μL) 200 μL
NCOA2-EIF4EBP1-20-REAQ 20 (40 μL) 200 μL
NCOA2-EIF4EBP1-20-ORRE 20 (40 μL) 200 μL
NCOA2-EIF4EBP1-20-OROR 20 (40 μL) 200 μL
NCOA2-EIF4EBP1-20-ORGO 20 (40 μL) 200 μL
NCOA2-EIF4EBP1-20-ORAQ 20 (40 μL) 200 μL
NCOA2-EIF4EBP1-20-GORE 20 (40 μL) 200 μL
NCOA2-EIF4EBP1-20-GOOR 20 (40 μL) 200 μL
NCOA2-EIF4EBP1-20-GOGO 20 (40 μL) 200 μL
NCOA2-EIF4EBP1-20-GOGR 20 (40 μL) 200 μL
NCOA2-EIF4EBP1-20-GOAQ 20 (40 μL) 200 μL
NCOA2-EIF4EBP1-20-GRRE 20 (40 μL) 200 μL
NCOA2-EIF4EBP1-20-GROR 20 (40 μL) 200 μL
NCOA2-EIF4EBP1-20-GRGO 20 (40 μL) 200 μL
NCOA2-EIF4EBP1-20-GRGR 20 (40 μL) 200 μL
NCOA2-EIF4EBP1-20-GRAQ 20 (40 μL) 200 μL
NCOA2-EIF4EBP1-20-AQRE 20 (40 μL) 200 μL
NCOA2-EIF4EBP1-20-AQOR 20 (40 μL) 200 μL
NCOA2-EIF4EBP1-20-AQGO 20 (40 μL) 200 μL
NCOA2-EIF4EBP1-20-AQGR 20 (40 μL) 200 μL
NCOA2-EIF4EBP1-20-AQAQ 20 (40 μL) 200 μL

EIF4EBP1 Gene Summary

This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation. [provided by RefSeq, Jul 2008]

Gene Name: Eukaryotic Translation Initiation Factor 4E Binding Protein 1

Chromosome: CHR8: 37888019 -37917883

Locus: 8p11.23

NCOA2 Gene Summary

The protein encoded by this gene functions as a transcriptional coactivator for nuclear hormone receptors, including steroid, thyroid, retinoid, and vitamin D receptors. The encoded protein acts as an intermediary factor for the ligand-dependent activity of these nuclear receptors, which regulate their target genes upon binding of cognate response elements. This gene has been found to be involved in translocations that result in fusions with other genes in various cancers, including the lysine acetyltransferase 6A (KAT6A) gene in acute myeloid leukemia, the ETS variant 6 (ETV6) gene in acute lymphoblastic leukemia, and the hes related family bHLH transcription factor with YRPW motif 1 (HEY1) gene in mesenchymal chondrosarcoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]

Gene Name: Nuclear Receptor Coactivator 2

Chromosome: CHR8: 71024266 -71316020

Locus: 8q13.3

Gene Diseases

The NCOA2 EIF4EBP1 Fusion has been associated with the following diseases:

Disease Name
Prostate Adenocarcinoma

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this probe.