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NCOA3-PADI1 Fusion FISH Probe

The NCOA3-PADI1 Fusion FISH Probe is used to confirm a fusion of the NCOA3 and PADI1 genes. The fusion of the NCOA3 and PADI1 genes has been associated with Uterine Corpus Endometrial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
NCOA3-PADI1-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
NCOA3-PADI1-20-RERE 20 (40 μL) 200 μL
NCOA3-PADI1-20-REOR 20 (40 μL) 200 μL
NCOA3-PADI1-20-REGO 20 (40 μL) 200 μL
NCOA3-PADI1-20-REGR 20 (40 μL) 200 μL
NCOA3-PADI1-20-REAQ 20 (40 μL) 200 μL
NCOA3-PADI1-20-ORRE 20 (40 μL) 200 μL
NCOA3-PADI1-20-OROR 20 (40 μL) 200 μL
NCOA3-PADI1-20-ORGO 20 (40 μL) 200 μL
NCOA3-PADI1-20-ORAQ 20 (40 μL) 200 μL
NCOA3-PADI1-20-GORE 20 (40 μL) 200 μL
NCOA3-PADI1-20-GOOR 20 (40 μL) 200 μL
NCOA3-PADI1-20-GOGO 20 (40 μL) 200 μL
NCOA3-PADI1-20-GOGR 20 (40 μL) 200 μL
NCOA3-PADI1-20-GOAQ 20 (40 μL) 200 μL
NCOA3-PADI1-20-GRRE 20 (40 μL) 200 μL
NCOA3-PADI1-20-GROR 20 (40 μL) 200 μL
NCOA3-PADI1-20-GRGO 20 (40 μL) 200 μL
NCOA3-PADI1-20-GRGR 20 (40 μL) 200 μL
NCOA3-PADI1-20-GRAQ 20 (40 μL) 200 μL
NCOA3-PADI1-20-AQRE 20 (40 μL) 200 μL
NCOA3-PADI1-20-AQOR 20 (40 μL) 200 μL
NCOA3-PADI1-20-AQGO 20 (40 μL) 200 μL
NCOA3-PADI1-20-AQGR 20 (40 μL) 200 μL
NCOA3-PADI1-20-AQAQ 20 (40 μL) 200 μL

NCOA3 Gene Summary

The protein encoded by this gene is a nuclear receptor coactivator that interacts with nuclear hormone receptors to enhance their transcriptional activator functions. The encoded protein has histone acetyltransferase activity and recruits p300/CBP-associated factor and CREB binding protein as part of a multisubunit coactivation complex. This protein is initially found in the cytoplasm but is translocated into the nucleus upon phosphorylation. Several transcript variants encoding different isoforms have been found for this gene. In addition, a polymorphic repeat region is found in the C-terminus of the encoded protein. [provided by RefSeq, Mar 2010]

Gene Name: Nuclear Receptor Coactivator 3

Chromosome: CHR20: 46130600 -46285621

Locus: 20q13.12

PADI1 Gene Summary

This gene encodes a member of the peptidyl arginine deiminase family of enzymes, which catalyze the post-translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions. The family members have distinct substrate specificities and tissue-specific expression patterns. The type I enzyme is involved in the late stages of epidermal differentiation, where it deiminates filaggrin and keratin K1, which maintains hydration of the stratum corneum, and hence the cutaneous barrier function. This enzyme may also play a role in hair follicle formation. This gene exists in a cluster with four other paralogous genes. [provided by RefSeq, Jul 2008]

Gene Name: Peptidyl Arginine Deiminase 1

Chromosome: CHR1: 17531620 -17572501

Locus: 1p36.13

Gene Diseases

The NCOA3 PADI1 Fusion has been associated with the following diseases:

Disease Name
Uterine Corpus Endometrial Carcinoma

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this probe.