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NCOA3-PTPRT Fusion FISH Probe

The NCOA3-PTPRT Fusion FISH Probe is used to confirm a fusion of the NCOA3 and PTPRT genes. The fusion of the NCOA3 and PTPRT genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
NCOA3-PTPRT-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
NCOA3-PTPRT-20-RERE 20 (40 μL) 200 μL
NCOA3-PTPRT-20-REOR 20 (40 μL) 200 μL
NCOA3-PTPRT-20-REGO 20 (40 μL) 200 μL
NCOA3-PTPRT-20-REGR 20 (40 μL) 200 μL
NCOA3-PTPRT-20-REAQ 20 (40 μL) 200 μL
NCOA3-PTPRT-20-ORRE 20 (40 μL) 200 μL
NCOA3-PTPRT-20-OROR 20 (40 μL) 200 μL
NCOA3-PTPRT-20-ORGO 20 (40 μL) 200 μL
NCOA3-PTPRT-20-ORAQ 20 (40 μL) 200 μL
NCOA3-PTPRT-20-GORE 20 (40 μL) 200 μL
NCOA3-PTPRT-20-GOOR 20 (40 μL) 200 μL
NCOA3-PTPRT-20-GOGO 20 (40 μL) 200 μL
NCOA3-PTPRT-20-GOGR 20 (40 μL) 200 μL
NCOA3-PTPRT-20-GOAQ 20 (40 μL) 200 μL
NCOA3-PTPRT-20-GRRE 20 (40 μL) 200 μL
NCOA3-PTPRT-20-GROR 20 (40 μL) 200 μL
NCOA3-PTPRT-20-GRGO 20 (40 μL) 200 μL
NCOA3-PTPRT-20-GRGR 20 (40 μL) 200 μL
NCOA3-PTPRT-20-GRAQ 20 (40 μL) 200 μL
NCOA3-PTPRT-20-AQRE 20 (40 μL) 200 μL
NCOA3-PTPRT-20-AQOR 20 (40 μL) 200 μL
NCOA3-PTPRT-20-AQGO 20 (40 μL) 200 μL
NCOA3-PTPRT-20-AQGR 20 (40 μL) 200 μL
NCOA3-PTPRT-20-AQAQ 20 (40 μL) 200 μL

NCOA3 Gene Summary

The protein encoded by this gene is a nuclear receptor coactivator that interacts with nuclear hormone receptors to enhance their transcriptional activator functions. The encoded protein has histone acetyltransferase activity and recruits p300/CBP-associated factor and CREB binding protein as part of a multisubunit coactivation complex. This protein is initially found in the cytoplasm but is translocated into the nucleus upon phosphorylation. Several transcript variants encoding different isoforms have been found for this gene. In addition, a polymorphic repeat region is found in the C-terminus of the encoded protein. [provided by RefSeq, Mar 2010]

Gene Name: Nuclear Receptor Coactivator 3

Chromosome: CHR20: 46130600 -46285621

Locus: 20q13.12

PTPRT Gene Summary

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracellular catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP (MAM) domain, Ig-like and fibronectin type III-like repeats. The protein domain structure and the expression pattern of the mouse counterpart of this PTP suggest its roles in both signal transduction and cellular adhesion in the central nervous system. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008]

Gene Name: Protein Tyrosine Phosphatase, Receptor Type T

Chromosome: CHR20: 40701391 -41818557

Locus: 20q12-q13.11

Gene Diseases

The NCOA3 PTPRT Fusion has been associated with the following diseases:

Disease Name
Sarcoma

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this probe.