NCOA4-MSMB Fusion FISH Probe
The NCOA4-MSMB Fusion FISH Probe is used to confirm a fusion of the NCOA4 and MSMB genes. The fusion of the NCOA4 and MSMB genes has been associated with Testicular Germ Cell Tumors, Lung Squamous Cell Carcinoma, and Bladder Urothelial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| NCOA4-MSMB-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| NCOA4-MSMB-20-RERE | 20 (40 μL) | 200 μL |
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| NCOA4-MSMB-20-REOR | 20 (40 μL) | 200 μL |
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| NCOA4-MSMB-20-REGO | 20 (40 μL) | 200 μL |
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| NCOA4-MSMB-20-REGR | 20 (40 μL) | 200 μL |
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| NCOA4-MSMB-20-REAQ | 20 (40 μL) | 200 μL |
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| NCOA4-MSMB-20-ORRE | 20 (40 μL) | 200 μL |
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| NCOA4-MSMB-20-OROR | 20 (40 μL) | 200 μL |
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| NCOA4-MSMB-20-ORGO | 20 (40 μL) | 200 μL |
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| NCOA4-MSMB-20-ORAQ | 20 (40 μL) | 200 μL |
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| NCOA4-MSMB-20-GORE | 20 (40 μL) | 200 μL |
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| NCOA4-MSMB-20-GOOR | 20 (40 μL) | 200 μL |
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| NCOA4-MSMB-20-GOGO | 20 (40 μL) | 200 μL |
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| NCOA4-MSMB-20-GOGR | 20 (40 μL) | 200 μL |
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| NCOA4-MSMB-20-GOAQ | 20 (40 μL) | 200 μL |
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| NCOA4-MSMB-20-GRRE | 20 (40 μL) | 200 μL |
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| NCOA4-MSMB-20-GROR | 20 (40 μL) | 200 μL |
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| NCOA4-MSMB-20-GRGO | 20 (40 μL) | 200 μL |
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| NCOA4-MSMB-20-GRGR | 20 (40 μL) | 200 μL |
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| NCOA4-MSMB-20-GRAQ | 20 (40 μL) | 200 μL |
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| NCOA4-MSMB-20-AQRE | 20 (40 μL) | 200 μL |
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| NCOA4-MSMB-20-AQOR | 20 (40 μL) | 200 μL |
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| NCOA4-MSMB-20-AQGO | 20 (40 μL) | 200 μL |
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| NCOA4-MSMB-20-AQGR | 20 (40 μL) | 200 μL |
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| NCOA4-MSMB-20-AQAQ | 20 (40 μL) | 200 μL |
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MSMB Gene Summary
The protein encoded by this gene is a member of the immunoglobulin binding factor family. It is synthesized by the epithelial cells of the prostate gland and secreted into the seminal plasma. This protein has inhibin-like activity. It may have a role as an autocrine paracrine factor in uterine, breast and other female reproductive tissues. The expression of the encoded protein is found to be decreased in prostate cancer. Two alternatively spliced transcript variants encoding different isoforms are described for this gene. The use of alternate polyadenylation sites has been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Microseminoprotein Beta
Chromosome: CHR10: 51549552 -51562518
Locus: 10q11.22
NCOA4 Gene Summary
This gene encodes an androgen receptor coactivator. The encoded protein interacts with the androgen receptor in a ligand-dependent manner to enhance its transcriptional activity. Chromosomal translocations between this gene and the ret tyrosine kinase gene, also located on chromosome 10, have been associated with papillary thyroid carcinoma. Alternatively spliced transcript variants have been described. Pseudogenes are present on chromosomes 4, 5, 10, and 14. [provided by RefSeq, Feb 2009]
Gene Name: Nuclear Receptor Coactivator 4
Chromosome: CHR10: 51565107 -51590734
Locus: 10q11.22
Gene Diseases
The NCOA4 MSMB Fusion has been associated with the following diseases:
| Disease Name |
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| Testicular Germ Cell Tumors |
| Lung Squamous Cell Carcinoma |
| Bladder Urothelial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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