NCOA5-CDH4 Fusion FISH Probe
The NCOA5-CDH4 Fusion FISH Probe is used to confirm a fusion of the NCOA5 and CDH4 genes. The fusion of the NCOA5 and CDH4 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| NCOA5-CDH4-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| NCOA5-CDH4-20-RERE | 20 (40 μL) | 200 μL |
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| NCOA5-CDH4-20-REOR | 20 (40 μL) | 200 μL |
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| NCOA5-CDH4-20-REGO | 20 (40 μL) | 200 μL |
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| NCOA5-CDH4-20-REGR | 20 (40 μL) | 200 μL |
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| NCOA5-CDH4-20-REAQ | 20 (40 μL) | 200 μL |
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| NCOA5-CDH4-20-ORRE | 20 (40 μL) | 200 μL |
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| NCOA5-CDH4-20-OROR | 20 (40 μL) | 200 μL |
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| NCOA5-CDH4-20-ORGO | 20 (40 μL) | 200 μL |
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| NCOA5-CDH4-20-ORAQ | 20 (40 μL) | 200 μL |
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| NCOA5-CDH4-20-GORE | 20 (40 μL) | 200 μL |
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| NCOA5-CDH4-20-GOOR | 20 (40 μL) | 200 μL |
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| NCOA5-CDH4-20-GOGO | 20 (40 μL) | 200 μL |
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| NCOA5-CDH4-20-GOGR | 20 (40 μL) | 200 μL |
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| NCOA5-CDH4-20-GOAQ | 20 (40 μL) | 200 μL |
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| NCOA5-CDH4-20-GRRE | 20 (40 μL) | 200 μL |
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| NCOA5-CDH4-20-GROR | 20 (40 μL) | 200 μL |
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| NCOA5-CDH4-20-GRGO | 20 (40 μL) | 200 μL |
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| NCOA5-CDH4-20-GRGR | 20 (40 μL) | 200 μL |
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| NCOA5-CDH4-20-GRAQ | 20 (40 μL) | 200 μL |
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| NCOA5-CDH4-20-AQRE | 20 (40 μL) | 200 μL |
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| NCOA5-CDH4-20-AQOR | 20 (40 μL) | 200 μL |
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| NCOA5-CDH4-20-AQGO | 20 (40 μL) | 200 μL |
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| NCOA5-CDH4-20-AQGR | 20 (40 μL) | 200 μL |
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| NCOA5-CDH4-20-AQAQ | 20 (40 μL) | 200 μL |
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CDH4 Gene Summary
This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Based on studies in chicken and mouse, this cadherin is thought to play an important role during brain segmentation and neuronal outgrowth. In addition, a role in kidney and muscle development is indicated. Of particular interest are studies showing stable cis-heterodimers of cadherins 2 and 4 in cotransfected cell lines. Previously thought to interact in an exclusively homophilic manner, this is the first evidence of cadherin heterodimerization. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
Gene Name: Cadherin 4
Chromosome: CHR20: 59827558 -60512299
Locus: 20q13.33
NCOA5 Gene Summary
This gene encodes a coregulator for the alpha and beta estrogen receptors and the orphan nuclear receptor NR1D2. The protein localizes to the nucleus, and is thought to have both coactivator and corepressor functions. Its interaction with nuclear receptors is independent of the AF2 domain on the receptors, which is known to regulate interaction with other coreceptors. Several alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2017]
Gene Name: Nuclear Receptor Coactivator 5
Chromosome: CHR20: 44689625 -44718580
Locus: 20q13.12
Gene Diseases
The NCOA5 CDH4 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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