NCOR1-ACACA Fusion FISH Probe
The NCOR1-ACACA Fusion FISH Probe is used to confirm a fusion of the NCOR1 and ACACA genes. The fusion of the NCOR1 and ACACA genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| NCOR1-ACACA-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| NCOR1-ACACA-20-RERE | 20 (40 μL) | 200 μL |
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| NCOR1-ACACA-20-REOR | 20 (40 μL) | 200 μL |
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| NCOR1-ACACA-20-REGO | 20 (40 μL) | 200 μL |
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| NCOR1-ACACA-20-REGR | 20 (40 μL) | 200 μL |
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| NCOR1-ACACA-20-REAQ | 20 (40 μL) | 200 μL |
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| NCOR1-ACACA-20-ORRE | 20 (40 μL) | 200 μL |
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| NCOR1-ACACA-20-OROR | 20 (40 μL) | 200 μL |
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| NCOR1-ACACA-20-ORGO | 20 (40 μL) | 200 μL |
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| NCOR1-ACACA-20-ORAQ | 20 (40 μL) | 200 μL |
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| NCOR1-ACACA-20-GORE | 20 (40 μL) | 200 μL |
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| NCOR1-ACACA-20-GOOR | 20 (40 μL) | 200 μL |
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| NCOR1-ACACA-20-GOGO | 20 (40 μL) | 200 μL |
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| NCOR1-ACACA-20-GOGR | 20 (40 μL) | 200 μL |
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| NCOR1-ACACA-20-GOAQ | 20 (40 μL) | 200 μL |
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| NCOR1-ACACA-20-GRRE | 20 (40 μL) | 200 μL |
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| NCOR1-ACACA-20-GROR | 20 (40 μL) | 200 μL |
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| NCOR1-ACACA-20-GRGO | 20 (40 μL) | 200 μL |
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| NCOR1-ACACA-20-GRGR | 20 (40 μL) | 200 μL |
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| NCOR1-ACACA-20-GRAQ | 20 (40 μL) | 200 μL |
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| NCOR1-ACACA-20-AQRE | 20 (40 μL) | 200 μL |
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| NCOR1-ACACA-20-AQOR | 20 (40 μL) | 200 μL |
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| NCOR1-ACACA-20-AQGO | 20 (40 μL) | 200 μL |
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| NCOR1-ACACA-20-AQGR | 20 (40 μL) | 200 μL |
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| NCOR1-ACACA-20-AQAQ | 20 (40 μL) | 200 μL |
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ACACA Gene Summary
Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. There are two ACC forms, alpha and beta, encoded by two different genes. ACC-alpha is highly enriched in lipogenic tissues. The enzyme is under long term control at the transcriptional and translational levels and under short term regulation by the phosphorylation/dephosphorylation of targeted serine residues and by allosteric transformation by citrate or palmitoyl-CoA. Multiple alternatively spliced transcript variants divergent in the 5' sequence and encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Acetyl-CoA Carboxylase Alpha
Chromosome: CHR17: 35441926 -35766902
Locus: 17q12
NCOR1 Gene Summary
This gene encodes a protein that mediates ligand-independent transcription repression of thyroid-hormone and retinoic-acid receptors by promoting chromatin condensation and preventing access of the transcription machinery. It is part of a complex which also includes histone deacetylases and transcriptional regulators similar to the yeast protein Sin3p. This gene is located between the Charcot-Marie-Tooth and Smith-Magenis syndrome critical regions on chromosome 17. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 17 and 20.[provided by RefSeq, Jun 2010]
Gene Name: Nuclear Receptor Corepressor 1
Chromosome: CHR17: 15933407 -16118874
Locus: 17p12-p11.2
Gene Diseases
The NCOR1 ACACA Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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