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NCOR1-DPM1 Fusion FISH Probe

The NCOR1-DPM1 Fusion FISH Probe is used to confirm a fusion of the NCOR1 and DPM1 genes. The fusion of the NCOR1 and DPM1 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
NCOR1-DPM1-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
NCOR1-DPM1-20-RERE 20 (40 μL) 200 μL
NCOR1-DPM1-20-REOR 20 (40 μL) 200 μL
NCOR1-DPM1-20-REGO 20 (40 μL) 200 μL
NCOR1-DPM1-20-REGR 20 (40 μL) 200 μL
NCOR1-DPM1-20-REAQ 20 (40 μL) 200 μL
NCOR1-DPM1-20-ORRE 20 (40 μL) 200 μL
NCOR1-DPM1-20-OROR 20 (40 μL) 200 μL
NCOR1-DPM1-20-ORGO 20 (40 μL) 200 μL
NCOR1-DPM1-20-ORAQ 20 (40 μL) 200 μL
NCOR1-DPM1-20-GORE 20 (40 μL) 200 μL
NCOR1-DPM1-20-GOOR 20 (40 μL) 200 μL
NCOR1-DPM1-20-GOGO 20 (40 μL) 200 μL
NCOR1-DPM1-20-GOGR 20 (40 μL) 200 μL
NCOR1-DPM1-20-GOAQ 20 (40 μL) 200 μL
NCOR1-DPM1-20-GRRE 20 (40 μL) 200 μL
NCOR1-DPM1-20-GROR 20 (40 μL) 200 μL
NCOR1-DPM1-20-GRGO 20 (40 μL) 200 μL
NCOR1-DPM1-20-GRGR 20 (40 μL) 200 μL
NCOR1-DPM1-20-GRAQ 20 (40 μL) 200 μL
NCOR1-DPM1-20-AQRE 20 (40 μL) 200 μL
NCOR1-DPM1-20-AQOR 20 (40 μL) 200 μL
NCOR1-DPM1-20-AQGO 20 (40 μL) 200 μL
NCOR1-DPM1-20-AQGR 20 (40 μL) 200 μL
NCOR1-DPM1-20-AQAQ 20 (40 μL) 200 μL

DPM1 Gene Summary

Dolichol-phosphate mannose (Dol-P-Man) serves as a donor of mannosyl residues on the lumenal side of the endoplasmic reticulum (ER). Lack of Dol-P-Man results in defective surface expression of GPI-anchored proteins. Dol-P-Man is synthesized from GDP-mannose and dolichol-phosphate on the cytosolic side of the ER by the enzyme dolichyl-phosphate mannosyltransferase. Human DPM1 lacks a carboxy-terminal transmembrane domain and signal sequence and is regulated by DPM2. Mutations in this gene are associated with congenital disorder of glycosylation type Ie. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2015]

Gene Name: Dolichyl-phosphate Mannosyltransferase Subunit 1, Catalytic

Chromosome: CHR20: 49551404 -49575060

Locus: 20q13.13

NCOR1 Gene Summary

This gene encodes a protein that mediates ligand-independent transcription repression of thyroid-hormone and retinoic-acid receptors by promoting chromatin condensation and preventing access of the transcription machinery. It is part of a complex which also includes histone deacetylases and transcriptional regulators similar to the yeast protein Sin3p. This gene is located between the Charcot-Marie-Tooth and Smith-Magenis syndrome critical regions on chromosome 17. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 17 and 20.[provided by RefSeq, Jun 2010]

Gene Name: Nuclear Receptor Corepressor 1

Chromosome: CHR17: 15933407 -16118874

Locus: 17p12-p11.2

Gene Diseases

The NCOR1 DPM1 Fusion has been associated with the following diseases:

Disease Name
Breast Invasive Carcinoma

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this probe.