NCOR2-PGC Fusion FISH Probe
The NCOR2-PGC Fusion FISH Probe is used to confirm a fusion of the NCOR2 and PGC genes. The fusion of the NCOR2 and PGC genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| NCOR2-PGC-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| NCOR2-PGC-20-RERE | 20 (40 μL) | 200 μL |
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| NCOR2-PGC-20-REOR | 20 (40 μL) | 200 μL |
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| NCOR2-PGC-20-REGO | 20 (40 μL) | 200 μL |
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| NCOR2-PGC-20-REGR | 20 (40 μL) | 200 μL |
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| NCOR2-PGC-20-REAQ | 20 (40 μL) | 200 μL |
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| NCOR2-PGC-20-ORRE | 20 (40 μL) | 200 μL |
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| NCOR2-PGC-20-OROR | 20 (40 μL) | 200 μL |
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| NCOR2-PGC-20-ORGO | 20 (40 μL) | 200 μL |
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| NCOR2-PGC-20-ORAQ | 20 (40 μL) | 200 μL |
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| NCOR2-PGC-20-GORE | 20 (40 μL) | 200 μL |
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| NCOR2-PGC-20-GOOR | 20 (40 μL) | 200 μL |
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| NCOR2-PGC-20-GOGO | 20 (40 μL) | 200 μL |
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| NCOR2-PGC-20-GOGR | 20 (40 μL) | 200 μL |
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| NCOR2-PGC-20-GOAQ | 20 (40 μL) | 200 μL |
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| NCOR2-PGC-20-GRRE | 20 (40 μL) | 200 μL |
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| NCOR2-PGC-20-GROR | 20 (40 μL) | 200 μL |
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| NCOR2-PGC-20-GRGO | 20 (40 μL) | 200 μL |
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| NCOR2-PGC-20-GRGR | 20 (40 μL) | 200 μL |
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| NCOR2-PGC-20-GRAQ | 20 (40 μL) | 200 μL |
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| NCOR2-PGC-20-AQRE | 20 (40 μL) | 200 μL |
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| NCOR2-PGC-20-AQOR | 20 (40 μL) | 200 μL |
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| NCOR2-PGC-20-AQGO | 20 (40 μL) | 200 μL |
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| NCOR2-PGC-20-AQGR | 20 (40 μL) | 200 μL |
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| NCOR2-PGC-20-AQAQ | 20 (40 μL) | 200 μL |
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PGC Gene Summary
This gene encodes an aspartic proteinase that belongs to the peptidase family A1. The encoded protein is a digestive enzyme that is produced in the stomach and constitutes a major component of the gastric mucosa. This protein is also secreted into the serum. This protein is synthesized as an inactive zymogen that includes a highly basic prosegment. This enzyme is converted into its active mature form at low pH by sequential cleavage of the prosegment that is carried out by the enzyme itself. Polymorphisms in this gene are associated with susceptibility to gastric cancers. Serum levels of this enzyme are used as a biomarker for certain gastric diseases including Helicobacter pylori related gastritis. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 1. [provided by RefSeq, Oct 2009]
Gene Name: Progastricsin
Chromosome: CHR6: 41704448 -41715139
Locus: 6p21.1
NCOR2 Gene Summary
This gene encodes a nuclear receptor co-repressor that mediates transcriptional silencing of certain target genes. The encoded protein is a member of a family of thyroid hormone- and retinoic acid receptor-associated co-repressors. This protein acts as part of a multisubunit complex which includes histone deacetylases to modify chromatin structure that prevents basal transcriptional activity of target genes. Aberrant expression of this gene is associated with certain cancers. Alternate splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Apr 2011]
Gene Name: Nuclear Receptor Corepressor 2
Chromosome: CHR12: 124808956 -125052010
Locus: 12q24.31
Gene Diseases
The NCOR2 PGC Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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