NCOR2-SCARB1 Fusion FISH Probe
The NCOR2-SCARB1 Fusion FISH Probe is used to confirm a fusion of the NCOR2 and SCARB1 genes. The fusion of the NCOR2 and SCARB1 genes has been associated with Esophageal Carcinoma, Lung Adenocarcinoma, Lung Adenocarcinoma, Breast Invasive Carcinoma, Stomach Adenocarcinoma, Uterine Corpus Endometrial Carcinoma, Esophageal Carcinoma, Esophageal Carcinoma, Adrenocortical Carcinoma, Sarcoma, and Stomach Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| NCOR2-SCARB1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| NCOR2-SCARB1-20-RERE | 20 (40 μL) | 200 μL |
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| NCOR2-SCARB1-20-REOR | 20 (40 μL) | 200 μL |
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| NCOR2-SCARB1-20-REGO | 20 (40 μL) | 200 μL |
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| NCOR2-SCARB1-20-REGR | 20 (40 μL) | 200 μL |
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| NCOR2-SCARB1-20-REAQ | 20 (40 μL) | 200 μL |
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| NCOR2-SCARB1-20-ORRE | 20 (40 μL) | 200 μL |
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| NCOR2-SCARB1-20-OROR | 20 (40 μL) | 200 μL |
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| NCOR2-SCARB1-20-ORGO | 20 (40 μL) | 200 μL |
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| NCOR2-SCARB1-20-ORAQ | 20 (40 μL) | 200 μL |
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| NCOR2-SCARB1-20-GORE | 20 (40 μL) | 200 μL |
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| NCOR2-SCARB1-20-GOOR | 20 (40 μL) | 200 μL |
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| NCOR2-SCARB1-20-GOGO | 20 (40 μL) | 200 μL |
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| NCOR2-SCARB1-20-GOGR | 20 (40 μL) | 200 μL |
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| NCOR2-SCARB1-20-GOAQ | 20 (40 μL) | 200 μL |
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| NCOR2-SCARB1-20-GRRE | 20 (40 μL) | 200 μL |
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| NCOR2-SCARB1-20-GROR | 20 (40 μL) | 200 μL |
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| NCOR2-SCARB1-20-GRGO | 20 (40 μL) | 200 μL |
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| NCOR2-SCARB1-20-GRGR | 20 (40 μL) | 200 μL |
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| NCOR2-SCARB1-20-GRAQ | 20 (40 μL) | 200 μL |
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| NCOR2-SCARB1-20-AQRE | 20 (40 μL) | 200 μL |
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| NCOR2-SCARB1-20-AQOR | 20 (40 μL) | 200 μL |
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| NCOR2-SCARB1-20-AQGO | 20 (40 μL) | 200 μL |
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| NCOR2-SCARB1-20-AQGR | 20 (40 μL) | 200 μL |
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| NCOR2-SCARB1-20-AQAQ | 20 (40 μL) | 200 μL |
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SCARB1 Gene Summary
The protein encoded by this gene is a plasma membrane receptor for high density lipoprotein cholesterol (HDL). The encoded protein mediates cholesterol transfer to and from HDL. In addition, this protein is a receptor for hepatitis C virus glycoprotein E2. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2011]
Gene Name: Scavenger Receptor Class B Member 1
Chromosome: CHR12: 125262173 -125348519
Locus: 12q24.31
NCOR2 Gene Summary
This gene encodes a nuclear receptor co-repressor that mediates transcriptional silencing of certain target genes. The encoded protein is a member of a family of thyroid hormone- and retinoic acid receptor-associated co-repressors. This protein acts as part of a multisubunit complex which includes histone deacetylases to modify chromatin structure that prevents basal transcriptional activity of target genes. Aberrant expression of this gene is associated with certain cancers. Alternate splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Apr 2011]
Gene Name: Nuclear Receptor Corepressor 2
Chromosome: CHR12: 124808956 -125052010
Locus: 12q24.31
Gene Diseases
The NCOR2 SCARB1 Fusion has been associated with the following diseases:
| Disease Name |
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| Esophageal Carcinoma |
| Lung Adenocarcinoma |
| Lung Adenocarcinoma |
| Breast Invasive Carcinoma |
| Stomach Adenocarcinoma |
| Uterine Corpus Endometrial Carcinoma |
| Esophageal Carcinoma |
| Esophageal Carcinoma |
| Adrenocortical Carcinoma |
| Sarcoma |
| Stomach Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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