NCSTN-SPRR2G Fusion FISH Probe
The NCSTN-SPRR2G Fusion FISH Probe is used to confirm a fusion of the NCSTN and SPRR2G genes. The fusion of the NCSTN and SPRR2G genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| NCSTN-SPRR2G-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| NCSTN-SPRR2G-20-RERE | 20 (40 μL) | 200 μL |
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| NCSTN-SPRR2G-20-REOR | 20 (40 μL) | 200 μL |
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| NCSTN-SPRR2G-20-REGO | 20 (40 μL) | 200 μL |
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| NCSTN-SPRR2G-20-REGR | 20 (40 μL) | 200 μL |
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| NCSTN-SPRR2G-20-REAQ | 20 (40 μL) | 200 μL |
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| NCSTN-SPRR2G-20-ORRE | 20 (40 μL) | 200 μL |
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| NCSTN-SPRR2G-20-OROR | 20 (40 μL) | 200 μL |
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| NCSTN-SPRR2G-20-ORGO | 20 (40 μL) | 200 μL |
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| NCSTN-SPRR2G-20-ORAQ | 20 (40 μL) | 200 μL |
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| NCSTN-SPRR2G-20-GORE | 20 (40 μL) | 200 μL |
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| NCSTN-SPRR2G-20-GOOR | 20 (40 μL) | 200 μL |
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| NCSTN-SPRR2G-20-GOGO | 20 (40 μL) | 200 μL |
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| NCSTN-SPRR2G-20-GOGR | 20 (40 μL) | 200 μL |
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| NCSTN-SPRR2G-20-GOAQ | 20 (40 μL) | 200 μL |
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| NCSTN-SPRR2G-20-GRRE | 20 (40 μL) | 200 μL |
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| NCSTN-SPRR2G-20-GROR | 20 (40 μL) | 200 μL |
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| NCSTN-SPRR2G-20-GRGO | 20 (40 μL) | 200 μL |
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| NCSTN-SPRR2G-20-GRGR | 20 (40 μL) | 200 μL |
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| NCSTN-SPRR2G-20-GRAQ | 20 (40 μL) | 200 μL |
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| NCSTN-SPRR2G-20-AQRE | 20 (40 μL) | 200 μL |
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| NCSTN-SPRR2G-20-AQOR | 20 (40 μL) | 200 μL |
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| NCSTN-SPRR2G-20-AQGO | 20 (40 μL) | 200 μL |
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| NCSTN-SPRR2G-20-AQGR | 20 (40 μL) | 200 μL |
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| NCSTN-SPRR2G-20-AQAQ | 20 (40 μL) | 200 μL |
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SPRR2G Gene Summary
The Small Proline Rich Protein 2G (SPRR2G) gene is located on chr1 :153122057-153123427 at 1q21.3.
Gene Name: Small Proline Rich Protein 2G
Chromosome: CHR1: 153122057 -153123427
Locus: 1q21.3
NCSTN Gene Summary
This gene encodes a type I transmembrane glycoprotein that is an integral component of the multimeric gamma-secretase complex. The encoded protein cleaves integral membrane proteins, including Notch receptors and beta-amyloid precursor protein, and may be a stabilizing cofactor required for gamma-secretase complex assembly. The cleavage of beta-amyloid precursor protein yields amyloid beta peptide, the main component of the neuritic plaque and the hallmark lesion in the brains of patients with Alzheimer's disease; however, the nature of the encoded protein's role in Alzheimer's disease is not known for certain. Mutations in this gene are associated with familial acne inversa. A pseudogene of this gene is present on chromosome 21. Alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Feb 2014]
Gene Name: Nicastrin
Chromosome: CHR1: 160313062 -160328742
Locus: 1q23.2
Gene Diseases
The NCSTN SPRR2G Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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