NDRG1-CLCN3 Fusion FISH Probe
The NDRG1-CLCN3 Fusion FISH Probe is used to confirm a fusion of the NDRG1 and CLCN3 genes. The fusion of the NDRG1 and CLCN3 genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| NDRG1-CLCN3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| NDRG1-CLCN3-20-RERE | 20 (40 μL) | 200 μL |
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| NDRG1-CLCN3-20-REOR | 20 (40 μL) | 200 μL |
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| NDRG1-CLCN3-20-REGO | 20 (40 μL) | 200 μL |
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| NDRG1-CLCN3-20-REGR | 20 (40 μL) | 200 μL |
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| NDRG1-CLCN3-20-REAQ | 20 (40 μL) | 200 μL |
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| NDRG1-CLCN3-20-ORRE | 20 (40 μL) | 200 μL |
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| NDRG1-CLCN3-20-OROR | 20 (40 μL) | 200 μL |
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| NDRG1-CLCN3-20-ORGO | 20 (40 μL) | 200 μL |
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| NDRG1-CLCN3-20-ORAQ | 20 (40 μL) | 200 μL |
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| NDRG1-CLCN3-20-GORE | 20 (40 μL) | 200 μL |
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| NDRG1-CLCN3-20-GOOR | 20 (40 μL) | 200 μL |
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| NDRG1-CLCN3-20-GOGO | 20 (40 μL) | 200 μL |
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| NDRG1-CLCN3-20-GOGR | 20 (40 μL) | 200 μL |
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| NDRG1-CLCN3-20-GOAQ | 20 (40 μL) | 200 μL |
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| NDRG1-CLCN3-20-GRRE | 20 (40 μL) | 200 μL |
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| NDRG1-CLCN3-20-GROR | 20 (40 μL) | 200 μL |
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| NDRG1-CLCN3-20-GRGO | 20 (40 μL) | 200 μL |
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| NDRG1-CLCN3-20-GRGR | 20 (40 μL) | 200 μL |
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| NDRG1-CLCN3-20-GRAQ | 20 (40 μL) | 200 μL |
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| NDRG1-CLCN3-20-AQRE | 20 (40 μL) | 200 μL |
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| NDRG1-CLCN3-20-AQOR | 20 (40 μL) | 200 μL |
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| NDRG1-CLCN3-20-AQGO | 20 (40 μL) | 200 μL |
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| NDRG1-CLCN3-20-AQGR | 20 (40 μL) | 200 μL |
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| NDRG1-CLCN3-20-AQAQ | 20 (40 μL) | 200 μL |
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CLCN3 Gene Summary
This gene encodes a member of the voltage-gated chloride channel (ClC) family. The encoded protein is present in all cell types and localized in plasma membranes and in intracellular vesicles. It is a multi-pass membrane protein which contains a ClC domain and two additional C-terminal CBS (cystathionine beta-synthase) domains. The ClC domain catalyzes the selective flow of Cl- ions across cell membranes, and the CBS domain may have a regulatory function. This protein plays a role in both acidification and transmitter loading of GABAergic synaptic vesicles, and in smooth muscle cell activation and neointima formation. This protein is required for lysophosphatidic acid (LPA)-activated Cl- current activity and fibroblast-to-myofibroblast differentiation. The protein activity is regulated by Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) in glioma cells. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]
Gene Name: Chloride Voltage-gated Channel 3
Chromosome: CHR4: 170541671 -170644338
Locus: 4q33
NDRG1 Gene Summary
This gene is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. The protein encoded by this gene is a cytoplasmic protein involved in stress responses, hormone responses, cell growth, and differentiation. The encoded protein is necessary for p53-mediated caspase activation and apoptosis. Mutations in this gene are a cause of Charcot-Marie-Tooth disease type 4D, and expression of this gene may be a prognostic indicator for several types of cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012]
Gene Name: N-myc Downstream Regulated 1
Chromosome: CHR8: 134249413 -134309547
Locus: 8q24.22
Gene Diseases
The NDRG1 CLCN3 Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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