NEDD4-GABRA5 Fusion FISH Probe
The NEDD4-GABRA5 Fusion FISH Probe is used to confirm a fusion of the NEDD4 and GABRA5 genes. The fusion of the NEDD4 and GABRA5 genes has been associated with Bladder Urothelial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| NEDD4-GABRA5-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| NEDD4-GABRA5-20-RERE | 20 (40 μL) | 200 μL |
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| NEDD4-GABRA5-20-REOR | 20 (40 μL) | 200 μL |
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| NEDD4-GABRA5-20-REGO | 20 (40 μL) | 200 μL |
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| NEDD4-GABRA5-20-REGR | 20 (40 μL) | 200 μL |
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| NEDD4-GABRA5-20-REAQ | 20 (40 μL) | 200 μL |
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| NEDD4-GABRA5-20-ORRE | 20 (40 μL) | 200 μL |
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| NEDD4-GABRA5-20-OROR | 20 (40 μL) | 200 μL |
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| NEDD4-GABRA5-20-ORGO | 20 (40 μL) | 200 μL |
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| NEDD4-GABRA5-20-ORAQ | 20 (40 μL) | 200 μL |
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| NEDD4-GABRA5-20-GORE | 20 (40 μL) | 200 μL |
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| NEDD4-GABRA5-20-GOOR | 20 (40 μL) | 200 μL |
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| NEDD4-GABRA5-20-GOGO | 20 (40 μL) | 200 μL |
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| NEDD4-GABRA5-20-GOGR | 20 (40 μL) | 200 μL |
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| NEDD4-GABRA5-20-GOAQ | 20 (40 μL) | 200 μL |
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| NEDD4-GABRA5-20-GRRE | 20 (40 μL) | 200 μL |
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| NEDD4-GABRA5-20-GROR | 20 (40 μL) | 200 μL |
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| NEDD4-GABRA5-20-GRGO | 20 (40 μL) | 200 μL |
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| NEDD4-GABRA5-20-GRGR | 20 (40 μL) | 200 μL |
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| NEDD4-GABRA5-20-GRAQ | 20 (40 μL) | 200 μL |
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| NEDD4-GABRA5-20-AQRE | 20 (40 μL) | 200 μL |
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| NEDD4-GABRA5-20-AQOR | 20 (40 μL) | 200 μL |
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| NEDD4-GABRA5-20-AQGO | 20 (40 μL) | 200 μL |
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| NEDD4-GABRA5-20-AQGR | 20 (40 μL) | 200 μL |
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| NEDD4-GABRA5-20-AQAQ | 20 (40 μL) | 200 μL |
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GABRA5 Gene Summary
GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. Transcript variants utilizing three different alternative non-coding first exons have been described. [provided by RefSeq, Jul 2008]
Gene Name: Gamma-aminobutyric Acid Type A Receptor Alpha5 Subunit
Chromosome: CHR15: 27111865 -27194357
Locus: 15q12
NEDD4 Gene Summary
This gene is the founding member of the NEDD4 family of HECT ubiquitin ligases that function in the ubiquitin proteasome system of protein degradation. The encoded protein contains an N-terminal calcium and phospholipid binding C2 domain followed by multiple tryptophan-rich WW domains and, a C-terminal HECT ubiquitin ligase catalytic domain. It plays critical role in the regulation of a number of membrane receptors, endocytic machinery components and the tumor suppressor PTEN. [provided by RefSeq, Jul 2016]
Gene Name: Neural Precursor Cell Expressed, Developmentally Down-regulated 4, E3 Ubiquitin Protein Ligase
Chromosome: CHR15: 56119121 -56285835
Locus: 15q21.3
Gene Diseases
The NEDD4 GABRA5 Fusion has been associated with the following diseases:
| Disease Name |
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| Bladder Urothelial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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