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NEDD4L-BCL2 Fusion FISH Probe

The NEDD4L-BCL2 Fusion FISH Probe is used to confirm a fusion of the NEDD4L and BCL2 genes. The fusion of the NEDD4L and BCL2 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
NEDD4L-BCL2-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
NEDD4L-BCL2-20-RERE 20 (40 μL) 200 μL
NEDD4L-BCL2-20-REOR 20 (40 μL) 200 μL
NEDD4L-BCL2-20-REGO 20 (40 μL) 200 μL
NEDD4L-BCL2-20-REGR 20 (40 μL) 200 μL
NEDD4L-BCL2-20-REAQ 20 (40 μL) 200 μL
NEDD4L-BCL2-20-ORRE 20 (40 μL) 200 μL
NEDD4L-BCL2-20-OROR 20 (40 μL) 200 μL
NEDD4L-BCL2-20-ORGO 20 (40 μL) 200 μL
NEDD4L-BCL2-20-ORAQ 20 (40 μL) 200 μL
NEDD4L-BCL2-20-GORE 20 (40 μL) 200 μL
NEDD4L-BCL2-20-GOOR 20 (40 μL) 200 μL
NEDD4L-BCL2-20-GOGO 20 (40 μL) 200 μL
NEDD4L-BCL2-20-GOGR 20 (40 μL) 200 μL
NEDD4L-BCL2-20-GOAQ 20 (40 μL) 200 μL
NEDD4L-BCL2-20-GRRE 20 (40 μL) 200 μL
NEDD4L-BCL2-20-GROR 20 (40 μL) 200 μL
NEDD4L-BCL2-20-GRGO 20 (40 μL) 200 μL
NEDD4L-BCL2-20-GRGR 20 (40 μL) 200 μL
NEDD4L-BCL2-20-GRAQ 20 (40 μL) 200 μL
NEDD4L-BCL2-20-AQRE 20 (40 μL) 200 μL
NEDD4L-BCL2-20-AQOR 20 (40 μL) 200 μL
NEDD4L-BCL2-20-AQGO 20 (40 μL) 200 μL
NEDD4L-BCL2-20-AQGR 20 (40 μL) 200 μL
NEDD4L-BCL2-20-AQAQ 20 (40 μL) 200 μL

BCL2 Gene Summary

This gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

Gene Name: BCL2, Apoptosis Regulator

Chromosome: CHR18: 60790578 -60986613

Locus: 18q21.33

NEDD4L Gene Summary

This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. The encoded protein mediates the ubiquitination of multiple target substrates and plays a critical role in epithelial sodium transport by regulating the cell surface expression of the epithelial sodium channel, ENaC. Single nucleotide polymorphisms in this gene may be associated with essential hypertension. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012]

Gene Name: Neural Precursor Cell Expressed, Developmentally Down-regulated 4-like, E3 Ubiquitin Protein Ligase

Chromosome: CHR18: 55711609 -56068772

Locus: 18q21.31

Gene Diseases

The NEDD4L BCL2 Fusion has been associated with the following diseases:

Disease Name
Breast Invasive Carcinoma

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this probe.