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NEK4-SETD2 Fusion FISH Probe

The NEK4-SETD2 Fusion FISH Probe is used to confirm a fusion of the NEK4 and SETD2 genes. The fusion of the NEK4 and SETD2 genes has been associated with Bladder Urothelial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
NEK4-SETD2-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
NEK4-SETD2-20-RERE 20 (40 μL) 200 μL
NEK4-SETD2-20-REOR 20 (40 μL) 200 μL
NEK4-SETD2-20-REGO 20 (40 μL) 200 μL
NEK4-SETD2-20-REGR 20 (40 μL) 200 μL
NEK4-SETD2-20-REAQ 20 (40 μL) 200 μL
NEK4-SETD2-20-ORRE 20 (40 μL) 200 μL
NEK4-SETD2-20-OROR 20 (40 μL) 200 μL
NEK4-SETD2-20-ORGO 20 (40 μL) 200 μL
NEK4-SETD2-20-ORAQ 20 (40 μL) 200 μL
NEK4-SETD2-20-GORE 20 (40 μL) 200 μL
NEK4-SETD2-20-GOOR 20 (40 μL) 200 μL
NEK4-SETD2-20-GOGO 20 (40 μL) 200 μL
NEK4-SETD2-20-GOGR 20 (40 μL) 200 μL
NEK4-SETD2-20-GOAQ 20 (40 μL) 200 μL
NEK4-SETD2-20-GRRE 20 (40 μL) 200 μL
NEK4-SETD2-20-GROR 20 (40 μL) 200 μL
NEK4-SETD2-20-GRGO 20 (40 μL) 200 μL
NEK4-SETD2-20-GRGR 20 (40 μL) 200 μL
NEK4-SETD2-20-GRAQ 20 (40 μL) 200 μL
NEK4-SETD2-20-AQRE 20 (40 μL) 200 μL
NEK4-SETD2-20-AQOR 20 (40 μL) 200 μL
NEK4-SETD2-20-AQGO 20 (40 μL) 200 μL
NEK4-SETD2-20-AQGR 20 (40 μL) 200 μL
NEK4-SETD2-20-AQAQ 20 (40 μL) 200 μL

NEK4 Gene Summary

The protein encoded by this gene is a serine/threonine protein kinase required for normal entry into replicative senescence. The encoded protein also is involved in cell cycle arrest in response to double-stranded DNA damage. Finally, this protein plays a role in maintaining cilium integrity, and defects in this gene have been associated with ciliopathies. [provided by RefSeq, Jan 2017]

Gene Name: NIMA Related Kinase 4

Chromosome: CHR3: 52744795 -52804965

Locus: 3p21.1

SETD2 Gene Summary

Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein belonging to a class of huntingtin interacting proteins characterized by WW motifs. This protein is a histone methyltransferase that is specific for lysine-36 of histone H3, and methylation of this residue is associated with active chromatin. This protein also contains a novel transcriptional activation domain and has been found associated with hyperphosphorylated RNA polymerase II. [provided by RefSeq, Aug 2008]

Gene Name: SET Domain Containing 2

Chromosome: CHR3: 47057897 -47205467

Locus: 3p21.31

Gene Diseases

The NEK4 SETD2 Fusion has been associated with the following diseases:

Disease Name
Bladder Urothelial Carcinoma

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this probe.