NFASC-CCNDBP1 Fusion FISH Probe
The NFASC-CCNDBP1 Fusion FISH Probe is used to confirm a fusion of the NFASC and CCNDBP1 genes. The fusion of the NFASC and CCNDBP1 genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| NFASC-CCNDBP1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| NFASC-CCNDBP1-20-RERE | 20 (40 μL) | 200 μL |
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| NFASC-CCNDBP1-20-REOR | 20 (40 μL) | 200 μL |
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| NFASC-CCNDBP1-20-REGO | 20 (40 μL) | 200 μL |
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| NFASC-CCNDBP1-20-REGR | 20 (40 μL) | 200 μL |
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| NFASC-CCNDBP1-20-REAQ | 20 (40 μL) | 200 μL |
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| NFASC-CCNDBP1-20-ORRE | 20 (40 μL) | 200 μL |
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| NFASC-CCNDBP1-20-OROR | 20 (40 μL) | 200 μL |
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| NFASC-CCNDBP1-20-ORGO | 20 (40 μL) | 200 μL |
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| NFASC-CCNDBP1-20-ORAQ | 20 (40 μL) | 200 μL |
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| NFASC-CCNDBP1-20-GORE | 20 (40 μL) | 200 μL |
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| NFASC-CCNDBP1-20-GOOR | 20 (40 μL) | 200 μL |
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| NFASC-CCNDBP1-20-GOGO | 20 (40 μL) | 200 μL |
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| NFASC-CCNDBP1-20-GOGR | 20 (40 μL) | 200 μL |
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| NFASC-CCNDBP1-20-GOAQ | 20 (40 μL) | 200 μL |
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| NFASC-CCNDBP1-20-GRRE | 20 (40 μL) | 200 μL |
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| NFASC-CCNDBP1-20-GROR | 20 (40 μL) | 200 μL |
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| NFASC-CCNDBP1-20-GRGO | 20 (40 μL) | 200 μL |
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| NFASC-CCNDBP1-20-GRGR | 20 (40 μL) | 200 μL |
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| NFASC-CCNDBP1-20-GRAQ | 20 (40 μL) | 200 μL |
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| NFASC-CCNDBP1-20-AQRE | 20 (40 μL) | 200 μL |
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| NFASC-CCNDBP1-20-AQOR | 20 (40 μL) | 200 μL |
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| NFASC-CCNDBP1-20-AQGO | 20 (40 μL) | 200 μL |
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| NFASC-CCNDBP1-20-AQGR | 20 (40 μL) | 200 μL |
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| NFASC-CCNDBP1-20-AQAQ | 20 (40 μL) | 200 μL |
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NFASC Gene Summary
This gene encodes an L1 family immunoglobulin cell adhesion molecule with multiple IGcam and fibronectin domains. The protein functions in neurite outgrowth, neurite fasciculation, and organization of the axon initial segment (AIS) and nodes of Ranvier on axons during early development. Both the AIS and nodes of Ranvier contain high densities of voltage-gated Na+ (Nav) channels which are clustered by interactions with cytoskeletal and scaffolding proteins including this protein, gliomedin, ankyrin 3 (ankyrin-G), and betaIV spectrin. This protein links the AIS extracellular matrix to the intracellular cytoskeleton. This gene undergoes extensive alternative splicing, and the full-length nature of some variants has not been determined.[provided by RefSeq, May 2009]
Gene Name: Neurofascin
Chromosome: CHR1: 204797781 -204991950
Locus: 1q32.1
CCNDBP1 Gene Summary
This gene was identified by the interaction of its gene product with Grap2, a leukocyte-specific adaptor protein important for immune cell signaling. The protein encoded by this gene was shown to interact with cyclin D. Transfection of this gene in cells was reported to reduce the phosphorylation of Rb gene product by cyclin D-dependent protein kinase, and inhibit E2F1-mediated transcription activity. This protein was also found to interact with helix-loop-helix protein E12 and is thought to be a negative regulator of liver-specific gene expression. Several alternatively spliced variants have been found for this gene. [provided by RefSeq, Apr 2009]
Gene Name: Cyclin D1 Binding Protein 1
Chromosome: CHR15: 43477465 -43489375
Locus: 15q15.2
Gene Diseases
The NFASC CCNDBP1 Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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