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NFASC-PRELP Fusion FISH Probe

The NFASC-PRELP Fusion FISH Probe is used to confirm a fusion of the NFASC and PRELP genes. The fusion of the NFASC and PRELP genes has been associated with Glioblastoma Multiforme, and Glioblastoma Multiforme. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
NFASC-PRELP-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
NFASC-PRELP-20-RERE 20 (40 μL) 200 μL
NFASC-PRELP-20-REOR 20 (40 μL) 200 μL
NFASC-PRELP-20-REGO 20 (40 μL) 200 μL
NFASC-PRELP-20-REGR 20 (40 μL) 200 μL
NFASC-PRELP-20-REAQ 20 (40 μL) 200 μL
NFASC-PRELP-20-ORRE 20 (40 μL) 200 μL
NFASC-PRELP-20-OROR 20 (40 μL) 200 μL
NFASC-PRELP-20-ORGO 20 (40 μL) 200 μL
NFASC-PRELP-20-ORAQ 20 (40 μL) 200 μL
NFASC-PRELP-20-GORE 20 (40 μL) 200 μL
NFASC-PRELP-20-GOOR 20 (40 μL) 200 μL
NFASC-PRELP-20-GOGO 20 (40 μL) 200 μL
NFASC-PRELP-20-GOGR 20 (40 μL) 200 μL
NFASC-PRELP-20-GOAQ 20 (40 μL) 200 μL
NFASC-PRELP-20-GRRE 20 (40 μL) 200 μL
NFASC-PRELP-20-GROR 20 (40 μL) 200 μL
NFASC-PRELP-20-GRGO 20 (40 μL) 200 μL
NFASC-PRELP-20-GRGR 20 (40 μL) 200 μL
NFASC-PRELP-20-GRAQ 20 (40 μL) 200 μL
NFASC-PRELP-20-AQRE 20 (40 μL) 200 μL
NFASC-PRELP-20-AQOR 20 (40 μL) 200 μL
NFASC-PRELP-20-AQGO 20 (40 μL) 200 μL
NFASC-PRELP-20-AQGR 20 (40 μL) 200 μL
NFASC-PRELP-20-AQAQ 20 (40 μL) 200 μL

PRELP Gene Summary

The protein encoded by this gene is a leucine-rich repeat protein present in connective tissue extracellular matrix. This protein functions as a molecule anchoring basement membranes to the underlying connective tissue. This protein has been shown to bind type I collagen to basement membranes and type II collagen to cartilage. It also binds the basement membrane heparan sulfate proteoglycan perlecan. This protein is suggested to be involved in the pathogenesis of Hutchinson-Gilford progeria (HGP), which is reported to lack the binding of collagen in basement membranes and cartilage. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008]

Gene Name: Proline And Arginine Rich End Leucine Rich Repeat Protein

Chromosome: CHR1: 203444882 -203460479

Locus: 1q32.1

NFASC Gene Summary

This gene encodes an L1 family immunoglobulin cell adhesion molecule with multiple IGcam and fibronectin domains. The protein functions in neurite outgrowth, neurite fasciculation, and organization of the axon initial segment (AIS) and nodes of Ranvier on axons during early development. Both the AIS and nodes of Ranvier contain high densities of voltage-gated Na+ (Nav) channels which are clustered by interactions with cytoskeletal and scaffolding proteins including this protein, gliomedin, ankyrin 3 (ankyrin-G), and betaIV spectrin. This protein links the AIS extracellular matrix to the intracellular cytoskeleton. This gene undergoes extensive alternative splicing, and the full-length nature of some variants has not been determined.[provided by RefSeq, May 2009]

Gene Name: Neurofascin

Chromosome: CHR1: 204797781 -204991950

Locus: 1q32.1

Gene Diseases

The NFASC PRELP Fusion has been associated with the following diseases:

Disease Name
Glioblastoma Multiforme
Glioblastoma Multiforme

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this probe.