NFE2L3-NPY Fusion FISH Probe
The NFE2L3-NPY Fusion FISH Probe is used to confirm a fusion of the NFE2L3 and NPY genes. The fusion of the NFE2L3 and NPY genes has been associated with Esophageal Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| NFE2L3-NPY-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| NFE2L3-NPY-20-RERE | 20 (40 μL) | 200 μL |
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| NFE2L3-NPY-20-REOR | 20 (40 μL) | 200 μL |
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| NFE2L3-NPY-20-REGO | 20 (40 μL) | 200 μL |
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| NFE2L3-NPY-20-REGR | 20 (40 μL) | 200 μL |
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| NFE2L3-NPY-20-REAQ | 20 (40 μL) | 200 μL |
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| NFE2L3-NPY-20-ORRE | 20 (40 μL) | 200 μL |
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| NFE2L3-NPY-20-OROR | 20 (40 μL) | 200 μL |
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| NFE2L3-NPY-20-ORGO | 20 (40 μL) | 200 μL |
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| NFE2L3-NPY-20-ORAQ | 20 (40 μL) | 200 μL |
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| NFE2L3-NPY-20-GORE | 20 (40 μL) | 200 μL |
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| NFE2L3-NPY-20-GOOR | 20 (40 μL) | 200 μL |
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| NFE2L3-NPY-20-GOGO | 20 (40 μL) | 200 μL |
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| NFE2L3-NPY-20-GOGR | 20 (40 μL) | 200 μL |
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| NFE2L3-NPY-20-GOAQ | 20 (40 μL) | 200 μL |
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| NFE2L3-NPY-20-GRRE | 20 (40 μL) | 200 μL |
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| NFE2L3-NPY-20-GROR | 20 (40 μL) | 200 μL |
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| NFE2L3-NPY-20-GRGO | 20 (40 μL) | 200 μL |
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| NFE2L3-NPY-20-GRGR | 20 (40 μL) | 200 μL |
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| NFE2L3-NPY-20-GRAQ | 20 (40 μL) | 200 μL |
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| NFE2L3-NPY-20-AQRE | 20 (40 μL) | 200 μL |
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| NFE2L3-NPY-20-AQOR | 20 (40 μL) | 200 μL |
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| NFE2L3-NPY-20-AQGO | 20 (40 μL) | 200 μL |
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| NFE2L3-NPY-20-AQGR | 20 (40 μL) | 200 μL |
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| NFE2L3-NPY-20-AQAQ | 20 (40 μL) | 200 μL |
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NPY Gene Summary
This gene encodes a neuropeptide that is widely expressed in the central nervous system and influences many physiological processes, including cortical excitability, stress response, food intake, circadian rhythms, and cardiovascular function. The neuropeptide functions through G protein-coupled receptors to inhibit adenylyl cyclase, activate mitogen-activated protein kinase (MAPK), regulate intracellular calcium levels, and activate potassium channels. A polymorphism in this gene resulting in a change of leucine 7 to proline in the signal peptide is associated with elevated cholesterol levels, higher alcohol consumption, and may be a risk factor for various metabolic and cardiovascular diseases. The protein also exhibits antimicrobial activity against bacteria and fungi. [provided by RefSeq, Oct 2014]
Gene Name: Neuropeptide Y
Chromosome: CHR7: 24323806 -24331484
Locus: 7p15.3
NFE2L3 Gene Summary
This gene encodes a member of the cap 'n' collar basic-region leucine zipper family of transcription factors. The encoded protein heterodimerizes with small musculoaponeurotic fibrosarcoma factors to bind antioxidant response elements in target genes. This protein is a membrane bound glycoprotein that is targeted to the endoplasmic reticulum and the nuclear envelope. Pseudogenes of this gene are found on chromosomes 16, 17, and 18. [provided by RefSeq, Mar 2009]
Gene Name: Nuclear Factor, Erythroid 2 Like 3
Chromosome: CHR7: 26191846 -26226756
Locus: 7p15.2
Gene Diseases
The NFE2L3 NPY Fusion has been associated with the following diseases:
| Disease Name |
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| Esophageal Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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