NFIX-CRYBB3 Fusion FISH Probe
The NFIX-CRYBB3 Fusion FISH Probe is used to confirm a fusion of the NFIX and CRYBB3 genes. The fusion of the NFIX and CRYBB3 genes has been associated with Bladder Urothelial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| NFIX-CRYBB3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| NFIX-CRYBB3-20-RERE | 20 (40 μL) | 200 μL |
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| NFIX-CRYBB3-20-REOR | 20 (40 μL) | 200 μL |
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| NFIX-CRYBB3-20-REGO | 20 (40 μL) | 200 μL |
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| NFIX-CRYBB3-20-REGR | 20 (40 μL) | 200 μL |
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| NFIX-CRYBB3-20-REAQ | 20 (40 μL) | 200 μL |
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| NFIX-CRYBB3-20-ORRE | 20 (40 μL) | 200 μL |
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| NFIX-CRYBB3-20-OROR | 20 (40 μL) | 200 μL |
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| NFIX-CRYBB3-20-ORGO | 20 (40 μL) | 200 μL |
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| NFIX-CRYBB3-20-ORAQ | 20 (40 μL) | 200 μL |
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| NFIX-CRYBB3-20-GORE | 20 (40 μL) | 200 μL |
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| NFIX-CRYBB3-20-GOOR | 20 (40 μL) | 200 μL |
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| NFIX-CRYBB3-20-GOGO | 20 (40 μL) | 200 μL |
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| NFIX-CRYBB3-20-GOGR | 20 (40 μL) | 200 μL |
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| NFIX-CRYBB3-20-GOAQ | 20 (40 μL) | 200 μL |
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| NFIX-CRYBB3-20-GRRE | 20 (40 μL) | 200 μL |
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| NFIX-CRYBB3-20-GROR | 20 (40 μL) | 200 μL |
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| NFIX-CRYBB3-20-GRGO | 20 (40 μL) | 200 μL |
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| NFIX-CRYBB3-20-GRGR | 20 (40 μL) | 200 μL |
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| NFIX-CRYBB3-20-GRAQ | 20 (40 μL) | 200 μL |
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| NFIX-CRYBB3-20-AQRE | 20 (40 μL) | 200 μL |
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| NFIX-CRYBB3-20-AQOR | 20 (40 μL) | 200 μL |
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| NFIX-CRYBB3-20-AQGO | 20 (40 μL) | 200 μL |
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| NFIX-CRYBB3-20-AQGR | 20 (40 μL) | 200 μL |
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| NFIX-CRYBB3-20-AQAQ | 20 (40 μL) | 200 μL |
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CRYBB3 Gene Summary
Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families; beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Beta-crystallins, the most heterogeneous, differ by the presence of the C-terminal extension (present in the basic group, none in the acidic group). Beta-crystallins form aggregates of different sizes and are able to self-associate to form dimers or to form heterodimers with other beta-crystallins. This gene, a beta basic group member, is part of a gene cluster with beta-A4, beta-B1, and beta-B2. Mutations in this gene result in cataract congenital nuclear autosomal recessive type 2. [provided by RefSeq, Feb 2013]
Gene Name: Crystallin Beta B3
Chromosome: CHR22: 25595824 -25603324
Locus: 22q11.23
NFIX Gene Summary
The protein encoded by this gene is a transcription factor that binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3 in viral and cellular promoters. The encoded protein can also stimulate adenovirus replication in vitro. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2012]
Gene Name: Nuclear Factor I X
Chromosome: CHR19: 13106583 -13209610
Locus: 19p13.13
Gene Diseases
The NFIX CRYBB3 Fusion has been associated with the following diseases:
| Disease Name |
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| Bladder Urothelial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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