NFKB1-MANBA Fusion FISH Probe
The NFKB1-MANBA Fusion FISH Probe is used to confirm a fusion of the NFKB1 and MANBA genes. The fusion of the NFKB1 and MANBA genes has been associated with Brain Lower Grade Glioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| NFKB1-MANBA-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
|
|
| NFKB1-MANBA-20-RERE | 20 (40 μL) | 200 μL |
|
|
| NFKB1-MANBA-20-REOR | 20 (40 μL) | 200 μL |
|
|
| NFKB1-MANBA-20-REGO | 20 (40 μL) | 200 μL |
|
|
| NFKB1-MANBA-20-REGR | 20 (40 μL) | 200 μL |
|
|
| NFKB1-MANBA-20-REAQ | 20 (40 μL) | 200 μL |
|
|
| NFKB1-MANBA-20-ORRE | 20 (40 μL) | 200 μL |
|
|
| NFKB1-MANBA-20-OROR | 20 (40 μL) | 200 μL |
|
|
| NFKB1-MANBA-20-ORGO | 20 (40 μL) | 200 μL |
|
|
| NFKB1-MANBA-20-ORAQ | 20 (40 μL) | 200 μL |
|
|
| NFKB1-MANBA-20-GORE | 20 (40 μL) | 200 μL |
|
|
| NFKB1-MANBA-20-GOOR | 20 (40 μL) | 200 μL |
|
|
| NFKB1-MANBA-20-GOGO | 20 (40 μL) | 200 μL |
|
|
| NFKB1-MANBA-20-GOGR | 20 (40 μL) | 200 μL |
|
|
| NFKB1-MANBA-20-GOAQ | 20 (40 μL) | 200 μL |
|
|
| NFKB1-MANBA-20-GRRE | 20 (40 μL) | 200 μL |
|
|
| NFKB1-MANBA-20-GROR | 20 (40 μL) | 200 μL |
|
|
| NFKB1-MANBA-20-GRGO | 20 (40 μL) | 200 μL |
|
|
| NFKB1-MANBA-20-GRGR | 20 (40 μL) | 200 μL |
|
|
| NFKB1-MANBA-20-GRAQ | 20 (40 μL) | 200 μL |
|
|
| NFKB1-MANBA-20-AQRE | 20 (40 μL) | 200 μL |
|
|
| NFKB1-MANBA-20-AQOR | 20 (40 μL) | 200 μL |
|
|
| NFKB1-MANBA-20-AQGO | 20 (40 μL) | 200 μL |
|
|
| NFKB1-MANBA-20-AQGR | 20 (40 μL) | 200 μL |
|
|
| NFKB1-MANBA-20-AQAQ | 20 (40 μL) | 200 μL |
|
MANBA Gene Summary
This gene encodes a member of the glycosyl hydrolase 2 family. The encoded protein localizes to the lysosome where it is the final exoglycosidase in the pathway for N-linked glycoprotein oligosaccharide catabolism. Mutations in this gene are associated with beta-mannosidosis, a lysosomal storage disease that has a wide spectrum of neurological involvement. [provided by RefSeq, Jul 2008]
Gene Name: Mannosidase Beta
Chromosome: CHR4: 103552642 -103682151
Locus: 4q24
NFKB1 Gene Summary
This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth. Alternative splicing results in multiple transcript variants encoding different isoforms, at least one of which is proteolytically processed. [provided by RefSeq, Feb 2016]
Gene Name: Nuclear Factor Kappa B Subunit 1
Chromosome: CHR4: 103422485 -103538459
Locus: 4q24
Gene Diseases
The NFKB1 MANBA Fusion has been associated with the following diseases:
| Disease Name |
|---|
| Brain Lower Grade Glioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|