NFYA-TREML2 Fusion FISH Probe
The NFYA-TREML2 Fusion FISH Probe is used to confirm a fusion of the NFYA and TREML2 genes. The fusion of the NFYA and TREML2 genes has been associated with Colon Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| NFYA-TREML2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| NFYA-TREML2-20-RERE | 20 (40 μL) | 200 μL |
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| NFYA-TREML2-20-REOR | 20 (40 μL) | 200 μL |
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| NFYA-TREML2-20-REGO | 20 (40 μL) | 200 μL |
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| NFYA-TREML2-20-REGR | 20 (40 μL) | 200 μL |
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| NFYA-TREML2-20-REAQ | 20 (40 μL) | 200 μL |
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| NFYA-TREML2-20-ORRE | 20 (40 μL) | 200 μL |
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| NFYA-TREML2-20-OROR | 20 (40 μL) | 200 μL |
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| NFYA-TREML2-20-ORGO | 20 (40 μL) | 200 μL |
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| NFYA-TREML2-20-ORAQ | 20 (40 μL) | 200 μL |
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| NFYA-TREML2-20-GORE | 20 (40 μL) | 200 μL |
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| NFYA-TREML2-20-GOOR | 20 (40 μL) | 200 μL |
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| NFYA-TREML2-20-GOGO | 20 (40 μL) | 200 μL |
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| NFYA-TREML2-20-GOGR | 20 (40 μL) | 200 μL |
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| NFYA-TREML2-20-GOAQ | 20 (40 μL) | 200 μL |
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| NFYA-TREML2-20-GRRE | 20 (40 μL) | 200 μL |
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| NFYA-TREML2-20-GROR | 20 (40 μL) | 200 μL |
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| NFYA-TREML2-20-GRGO | 20 (40 μL) | 200 μL |
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| NFYA-TREML2-20-GRGR | 20 (40 μL) | 200 μL |
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| NFYA-TREML2-20-GRAQ | 20 (40 μL) | 200 μL |
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| NFYA-TREML2-20-AQRE | 20 (40 μL) | 200 μL |
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| NFYA-TREML2-20-AQOR | 20 (40 μL) | 200 μL |
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| NFYA-TREML2-20-AQGO | 20 (40 μL) | 200 μL |
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| NFYA-TREML2-20-AQGR | 20 (40 μL) | 200 μL |
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| NFYA-TREML2-20-AQAQ | 20 (40 μL) | 200 μL |
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NFYA Gene Summary
The protein encoded by this gene is one subunit of a trimeric complex, forming a highly conserved transcription factor that binds to CCAAT motifs in the promoter regions in a variety of genes. Subunit A associates with a tight dimer composed of the B and C subunits, resulting in a trimer that binds to DNA with high specificity and affinity. The sequence specific interactions of the complex are made by the A subunit, suggesting a role as the regulatory subunit. In addition, there is evidence of post-transcriptional regulation in this gene product, either by protein degradation or control of translation. Further regulation is represented by alternative splicing in the glutamine-rich activation domain, with clear tissue-specific preferences for the two isoforms. [provided by RefSeq, Jul 2008]
Gene Name: Nuclear Transcription Factor Y Subunit Alpha
Chromosome: CHR6: 41040706 -41070146
Locus: 6p21.1
TREML2 Gene Summary
TREML2 is located in a gene cluster on chromosome 6 with the single Ig variable (IgV) domain activating receptors TREM1 (MIM 605085) and TREM2 (MIM 605086), but it has distinct structural and functional properties (Allcock et al., 2003 [PubMed 12645956]).[supplied by OMIM, Mar 2008]
Gene Name: Triggering Receptor Expressed On Myeloid Cells Like 2
Chromosome: CHR6: 41157551 -41168925
Locus: 6p21.1
Gene Diseases
The NFYA TREML2 Fusion has been associated with the following diseases:
| Disease Name |
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| Colon Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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