NIPBL-ATP2A2 Fusion FISH Probe
The NIPBL-ATP2A2 Fusion FISH Probe is used to confirm a fusion of the NIPBL and ATP2A2 genes. The fusion of the NIPBL and ATP2A2 genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| NIPBL-ATP2A2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| NIPBL-ATP2A2-20-RERE | 20 (40 μL) | 200 μL |
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| NIPBL-ATP2A2-20-REOR | 20 (40 μL) | 200 μL |
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| NIPBL-ATP2A2-20-REGO | 20 (40 μL) | 200 μL |
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| NIPBL-ATP2A2-20-REGR | 20 (40 μL) | 200 μL |
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| NIPBL-ATP2A2-20-REAQ | 20 (40 μL) | 200 μL |
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| NIPBL-ATP2A2-20-ORRE | 20 (40 μL) | 200 μL |
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| NIPBL-ATP2A2-20-OROR | 20 (40 μL) | 200 μL |
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| NIPBL-ATP2A2-20-ORGO | 20 (40 μL) | 200 μL |
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| NIPBL-ATP2A2-20-ORAQ | 20 (40 μL) | 200 μL |
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| NIPBL-ATP2A2-20-GORE | 20 (40 μL) | 200 μL |
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| NIPBL-ATP2A2-20-GOOR | 20 (40 μL) | 200 μL |
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| NIPBL-ATP2A2-20-GOGO | 20 (40 μL) | 200 μL |
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| NIPBL-ATP2A2-20-GOGR | 20 (40 μL) | 200 μL |
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| NIPBL-ATP2A2-20-GOAQ | 20 (40 μL) | 200 μL |
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| NIPBL-ATP2A2-20-GRRE | 20 (40 μL) | 200 μL |
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| NIPBL-ATP2A2-20-GROR | 20 (40 μL) | 200 μL |
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| NIPBL-ATP2A2-20-GRGO | 20 (40 μL) | 200 μL |
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| NIPBL-ATP2A2-20-GRGR | 20 (40 μL) | 200 μL |
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| NIPBL-ATP2A2-20-GRAQ | 20 (40 μL) | 200 μL |
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| NIPBL-ATP2A2-20-AQRE | 20 (40 μL) | 200 μL |
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| NIPBL-ATP2A2-20-AQOR | 20 (40 μL) | 200 μL |
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| NIPBL-ATP2A2-20-AQGO | 20 (40 μL) | 200 μL |
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| NIPBL-ATP2A2-20-AQGR | 20 (40 μL) | 200 μL |
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| NIPBL-ATP2A2-20-AQAQ | 20 (40 μL) | 200 μL |
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ATP2A2 Gene Summary
This gene encodes one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol into the sarcoplasmic reticulum lumen, and is involved in regulation of the contraction/relaxation cycle. Mutations in this gene cause Darier-White disease, also known as keratosis follicularis, an autosomal dominant skin disorder characterized by loss of adhesion between epidermal cells and abnormal keratinization. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2008]
Gene Name: ATPase Sarcoplasmic/endoplasmic Reticulum Ca2+ Transporting 2
Chromosome: CHR12: 110719031 -110788897
Locus: 12q24.11
NIPBL Gene Summary
This gene encodes the homolog of the Drosophila melanogaster Nipped-B gene product and fungal Scc2-type sister chromatid cohesion proteins. The Drosophila protein facilitates enhancer-promoter communication of remote enhancers and plays a role in developmental regulation. It is also homologous to a family of chromosomal adherins with broad roles in sister chromatid cohesion, chromosome condensation, and DNA repair. The human protein has a bipartite nuclear targeting sequence and a putative HEAT repeat. Condensins, cohesins and other complexes with chromosome-related functions also contain HEAT repeats. Mutations in this gene result in Cornelia de Lange syndrome, a disorder characterized by dysmorphic facial features, growth delay, limb reduction defects, and cognitive disability. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: NIPBL, Cohesin Loading Factor
Chromosome: CHR5: 36876860 -37065921
Locus: 5p13.2
Gene Diseases
The NIPBL ATP2A2 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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