NOTCH2-PSMA5 Fusion FISH Probe
The NOTCH2-PSMA5 Fusion FISH Probe is used to confirm a fusion of the NOTCH2 and PSMA5 genes. The fusion of the NOTCH2 and PSMA5 genes has been associated with Ovarian Serous Cystadenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| NOTCH2-PSMA5-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| NOTCH2-PSMA5-20-RERE | 20 (40 μL) | 200 μL |
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| NOTCH2-PSMA5-20-REOR | 20 (40 μL) | 200 μL |
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| NOTCH2-PSMA5-20-REGO | 20 (40 μL) | 200 μL |
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| NOTCH2-PSMA5-20-REGR | 20 (40 μL) | 200 μL |
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| NOTCH2-PSMA5-20-REAQ | 20 (40 μL) | 200 μL |
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| NOTCH2-PSMA5-20-ORRE | 20 (40 μL) | 200 μL |
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| NOTCH2-PSMA5-20-OROR | 20 (40 μL) | 200 μL |
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| NOTCH2-PSMA5-20-ORGO | 20 (40 μL) | 200 μL |
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| NOTCH2-PSMA5-20-ORAQ | 20 (40 μL) | 200 μL |
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| NOTCH2-PSMA5-20-GORE | 20 (40 μL) | 200 μL |
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| NOTCH2-PSMA5-20-GOOR | 20 (40 μL) | 200 μL |
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| NOTCH2-PSMA5-20-GOGO | 20 (40 μL) | 200 μL |
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| NOTCH2-PSMA5-20-GOGR | 20 (40 μL) | 200 μL |
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| NOTCH2-PSMA5-20-GOAQ | 20 (40 μL) | 200 μL |
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| NOTCH2-PSMA5-20-GRRE | 20 (40 μL) | 200 μL |
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| NOTCH2-PSMA5-20-GROR | 20 (40 μL) | 200 μL |
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| NOTCH2-PSMA5-20-GRGO | 20 (40 μL) | 200 μL |
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| NOTCH2-PSMA5-20-GRGR | 20 (40 μL) | 200 μL |
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| NOTCH2-PSMA5-20-GRAQ | 20 (40 μL) | 200 μL |
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| NOTCH2-PSMA5-20-AQRE | 20 (40 μL) | 200 μL |
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| NOTCH2-PSMA5-20-AQOR | 20 (40 μL) | 200 μL |
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| NOTCH2-PSMA5-20-AQGO | 20 (40 μL) | 200 μL |
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| NOTCH2-PSMA5-20-AQGR | 20 (40 μL) | 200 μL |
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| NOTCH2-PSMA5-20-AQAQ | 20 (40 μL) | 200 μL |
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NOTCH2 Gene Summary
This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play a role in vascular, renal and hepatic development. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]
Gene Name: Notch 2
Chromosome: CHR1: 120454175 -120612317
Locus: 1p12
PSMA5 Gene Summary
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. Multiple alternatively spliced transcript variants encoding two distinct isoforms have been found for this gene. [provided by RefSeq, Dec 2010]
Gene Name: Proteasome Subunit Alpha 5
Chromosome: CHR1: 109941652 -109969108
Locus: 1p13.3
Gene Diseases
The NOTCH2 PSMA5 Fusion has been associated with the following diseases:
| Disease Name |
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| Ovarian Serous Cystadenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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