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NPC1-OSBPL1A Fusion FISH Probe

The NPC1-OSBPL1A Fusion FISH Probe is used to confirm a fusion of the NPC1 and OSBPL1A genes. The fusion of the NPC1 and OSBPL1A genes has been associated with Uterine Corpus Endometrial Carcinoma, and Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
NPC1-OSBPL1A-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
NPC1-OSBPL1A-20-RERE 20 (40 μL) 200 μL
NPC1-OSBPL1A-20-REOR 20 (40 μL) 200 μL
NPC1-OSBPL1A-20-REGO 20 (40 μL) 200 μL
NPC1-OSBPL1A-20-REGR 20 (40 μL) 200 μL
NPC1-OSBPL1A-20-REAQ 20 (40 μL) 200 μL
NPC1-OSBPL1A-20-ORRE 20 (40 μL) 200 μL
NPC1-OSBPL1A-20-OROR 20 (40 μL) 200 μL
NPC1-OSBPL1A-20-ORGO 20 (40 μL) 200 μL
NPC1-OSBPL1A-20-ORAQ 20 (40 μL) 200 μL
NPC1-OSBPL1A-20-GORE 20 (40 μL) 200 μL
NPC1-OSBPL1A-20-GOOR 20 (40 μL) 200 μL
NPC1-OSBPL1A-20-GOGO 20 (40 μL) 200 μL
NPC1-OSBPL1A-20-GOGR 20 (40 μL) 200 μL
NPC1-OSBPL1A-20-GOAQ 20 (40 μL) 200 μL
NPC1-OSBPL1A-20-GRRE 20 (40 μL) 200 μL
NPC1-OSBPL1A-20-GROR 20 (40 μL) 200 μL
NPC1-OSBPL1A-20-GRGO 20 (40 μL) 200 μL
NPC1-OSBPL1A-20-GRGR 20 (40 μL) 200 μL
NPC1-OSBPL1A-20-GRAQ 20 (40 μL) 200 μL
NPC1-OSBPL1A-20-AQRE 20 (40 μL) 200 μL
NPC1-OSBPL1A-20-AQOR 20 (40 μL) 200 μL
NPC1-OSBPL1A-20-AQGO 20 (40 μL) 200 μL
NPC1-OSBPL1A-20-AQGR 20 (40 μL) 200 μL
NPC1-OSBPL1A-20-AQAQ 20 (40 μL) 200 μL

NPC1 Gene Summary

This gene encodes a large protein that resides in the limiting membrane of endosomes and lysosomes and mediates intracellular cholesterol trafficking via binding of cholesterol to its N-terminal domain. It is predicted to have a cytoplasmic C-terminus, 13 transmembrane domains, and 3 large loops in the lumen of the endosome - the last loop being at the N-terminus. This protein transports low-density lipoproteins to late endosomal/lysosomal compartments where they are hydrolized and released as free cholesterol. Defects in this gene cause Niemann-Pick type C disease, a rare autosomal recessive neurodegenerative disorder characterized by over accumulation of cholesterol and glycosphingolipids in late endosomal/lysosomal compartments.[provided by RefSeq, Aug 2009]

Gene Name: NPC Intracellular Cholesterol Transporter 1

Chromosome: CHR18: 21111462 -21166581

Locus: 18q11.2

OSBPL1A Gene Summary

This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain, although some members contain only the sterol-binding domain. Transcript variants derived from alternative promoter usage and/or alternative splicing exist; they encode different isoforms. [provided by RefSeq, Jul 2008]

Gene Name: Oxysterol Binding Protein Like 1A

Chromosome: CHR18: 21742010 -21977833

Locus: 18q11.2

Gene Diseases

The NPC1 OSBPL1A Fusion has been associated with the following diseases:

Disease Name
Uterine Corpus Endometrial Carcinoma
Prostate Adenocarcinoma

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this probe.