NPY-DDX21 Fusion FISH Probe
The NPY-DDX21 Fusion FISH Probe is used to confirm a fusion of the NPY and DDX21 genes. The fusion of the NPY and DDX21 genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| NPY-DDX21-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| NPY-DDX21-20-RERE | 20 (40 μL) | 200 μL |
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| NPY-DDX21-20-REOR | 20 (40 μL) | 200 μL |
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| NPY-DDX21-20-REGO | 20 (40 μL) | 200 μL |
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| NPY-DDX21-20-REGR | 20 (40 μL) | 200 μL |
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| NPY-DDX21-20-REAQ | 20 (40 μL) | 200 μL |
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| NPY-DDX21-20-ORRE | 20 (40 μL) | 200 μL |
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| NPY-DDX21-20-OROR | 20 (40 μL) | 200 μL |
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| NPY-DDX21-20-ORGO | 20 (40 μL) | 200 μL |
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| NPY-DDX21-20-ORAQ | 20 (40 μL) | 200 μL |
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| NPY-DDX21-20-GORE | 20 (40 μL) | 200 μL |
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| NPY-DDX21-20-GOOR | 20 (40 μL) | 200 μL |
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| NPY-DDX21-20-GOGO | 20 (40 μL) | 200 μL |
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| NPY-DDX21-20-GOGR | 20 (40 μL) | 200 μL |
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| NPY-DDX21-20-GOAQ | 20 (40 μL) | 200 μL |
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| NPY-DDX21-20-GRRE | 20 (40 μL) | 200 μL |
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| NPY-DDX21-20-GROR | 20 (40 μL) | 200 μL |
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| NPY-DDX21-20-GRGO | 20 (40 μL) | 200 μL |
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| NPY-DDX21-20-GRGR | 20 (40 μL) | 200 μL |
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| NPY-DDX21-20-GRAQ | 20 (40 μL) | 200 μL |
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| NPY-DDX21-20-AQRE | 20 (40 μL) | 200 μL |
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| NPY-DDX21-20-AQOR | 20 (40 μL) | 200 μL |
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| NPY-DDX21-20-AQGO | 20 (40 μL) | 200 μL |
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| NPY-DDX21-20-AQGR | 20 (40 μL) | 200 μL |
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| NPY-DDX21-20-AQAQ | 20 (40 μL) | 200 μL |
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NPY Gene Summary
This gene encodes a neuropeptide that is widely expressed in the central nervous system and influences many physiological processes, including cortical excitability, stress response, food intake, circadian rhythms, and cardiovascular function. The neuropeptide functions through G protein-coupled receptors to inhibit adenylyl cyclase, activate mitogen-activated protein kinase (MAPK), regulate intracellular calcium levels, and activate potassium channels. A polymorphism in this gene resulting in a change of leucine 7 to proline in the signal peptide is associated with elevated cholesterol levels, higher alcohol consumption, and may be a risk factor for various metabolic and cardiovascular diseases. The protein also exhibits antimicrobial activity against bacteria and fungi. [provided by RefSeq, Oct 2014]
Gene Name: Neuropeptide Y
Chromosome: CHR7: 24323806 -24331484
Locus: 7p15.3
DDX21 Gene Summary
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is an antigen recognized by autoimmune antibodies from a patient with watermelon stomach disease. This protein unwinds double-stranded RNA, folds single-stranded RNA, and may play important roles in ribosomal RNA biogenesis, RNA editing, RNA transport, and general transcription. [provided by RefSeq, Jul 2008]
Gene Name: DExD-box Helicase 21
Chromosome: CHR10: 70715891 -70744279
Locus: 10q22.1
Gene Diseases
The NPY DDX21 Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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