NRCAM-TLN1 Fusion FISH Probe
The NRCAM-TLN1 Fusion FISH Probe is used to confirm a fusion of the NRCAM and TLN1 genes. The fusion of the NRCAM and TLN1 genes has been associated with Brain Lower Grade Glioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| NRCAM-TLN1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| NRCAM-TLN1-20-RERE | 20 (40 μL) | 200 μL |
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| NRCAM-TLN1-20-REOR | 20 (40 μL) | 200 μL |
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| NRCAM-TLN1-20-REGO | 20 (40 μL) | 200 μL |
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| NRCAM-TLN1-20-REGR | 20 (40 μL) | 200 μL |
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| NRCAM-TLN1-20-REAQ | 20 (40 μL) | 200 μL |
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| NRCAM-TLN1-20-ORRE | 20 (40 μL) | 200 μL |
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| NRCAM-TLN1-20-OROR | 20 (40 μL) | 200 μL |
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| NRCAM-TLN1-20-ORGO | 20 (40 μL) | 200 μL |
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| NRCAM-TLN1-20-ORAQ | 20 (40 μL) | 200 μL |
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| NRCAM-TLN1-20-GORE | 20 (40 μL) | 200 μL |
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| NRCAM-TLN1-20-GOOR | 20 (40 μL) | 200 μL |
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| NRCAM-TLN1-20-GOGO | 20 (40 μL) | 200 μL |
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| NRCAM-TLN1-20-GOGR | 20 (40 μL) | 200 μL |
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| NRCAM-TLN1-20-GOAQ | 20 (40 μL) | 200 μL |
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| NRCAM-TLN1-20-GRRE | 20 (40 μL) | 200 μL |
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| NRCAM-TLN1-20-GROR | 20 (40 μL) | 200 μL |
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| NRCAM-TLN1-20-GRGO | 20 (40 μL) | 200 μL |
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| NRCAM-TLN1-20-GRGR | 20 (40 μL) | 200 μL |
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| NRCAM-TLN1-20-GRAQ | 20 (40 μL) | 200 μL |
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| NRCAM-TLN1-20-AQRE | 20 (40 μL) | 200 μL |
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| NRCAM-TLN1-20-AQOR | 20 (40 μL) | 200 μL |
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| NRCAM-TLN1-20-AQGO | 20 (40 μL) | 200 μL |
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| NRCAM-TLN1-20-AQGR | 20 (40 μL) | 200 μL |
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| NRCAM-TLN1-20-AQAQ | 20 (40 μL) | 200 μL |
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NRCAM Gene Summary
Cell adhesion molecules (CAMs) are members of the immunoglobulin superfamily. This gene encodes a neuronal cell adhesion molecule with multiple immunoglobulin-like C2-type domains and fibronectin type-III domains. This ankyrin-binding protein is involved in neuron-neuron adhesion and promotes directional signaling during axonal cone growth. This gene is also expressed in non-neural tissues and may play a general role in cell-cell communication via signaling from its intracellular domain to the actin cytoskeleton during directional cell migration. Allelic variants of this gene have been associated with autism and addiction vulnerability. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Gene Name: Neuronal Cell Adhesion Molecule
Chromosome: CHR7: 107788070 -108096841
Locus: 7q31.1
TLN1 Gene Summary
This gene encodes a cytoskeletal protein that is concentrated in areas of cell-substratum and cell-cell contacts. The encoded protein plays a significant role in the assembly of actin filaments and in spreading and migration of various cell types, including fibroblasts and osteoclasts. It codistributes with integrins in the cell surface membrane in order to assist in the attachment of adherent cells to extracellular matrices and of lymphocytes to other cells. The N-terminus of this protein contains elements for localization to cell-extracellular matrix junctions. The C-terminus contains binding sites for proteins such as beta-1-integrin, actin, and vinculin. [provided by RefSeq, Feb 2009]
Gene Name: Talin 1
Chromosome: CHR9: 35697333 -35732392
Locus: 9p13.3
Gene Diseases
The NRCAM TLN1 Fusion has been associated with the following diseases:
| Disease Name |
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| Brain Lower Grade Glioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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