NRP1-CUL2 Fusion FISH Probe
The NRP1-CUL2 Fusion FISH Probe is used to confirm a fusion of the NRP1 and CUL2 genes. The fusion of the NRP1 and CUL2 genes has been associated with Brain Lower Grade Glioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| NRP1-CUL2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| NRP1-CUL2-20-RERE | 20 (40 μL) | 200 μL |
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| NRP1-CUL2-20-REOR | 20 (40 μL) | 200 μL |
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| NRP1-CUL2-20-REGO | 20 (40 μL) | 200 μL |
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| NRP1-CUL2-20-REGR | 20 (40 μL) | 200 μL |
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| NRP1-CUL2-20-REAQ | 20 (40 μL) | 200 μL |
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| NRP1-CUL2-20-ORRE | 20 (40 μL) | 200 μL |
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| NRP1-CUL2-20-OROR | 20 (40 μL) | 200 μL |
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| NRP1-CUL2-20-ORGO | 20 (40 μL) | 200 μL |
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| NRP1-CUL2-20-ORAQ | 20 (40 μL) | 200 μL |
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| NRP1-CUL2-20-GORE | 20 (40 μL) | 200 μL |
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| NRP1-CUL2-20-GOOR | 20 (40 μL) | 200 μL |
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| NRP1-CUL2-20-GOGO | 20 (40 μL) | 200 μL |
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| NRP1-CUL2-20-GOGR | 20 (40 μL) | 200 μL |
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| NRP1-CUL2-20-GOAQ | 20 (40 μL) | 200 μL |
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| NRP1-CUL2-20-GRRE | 20 (40 μL) | 200 μL |
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| NRP1-CUL2-20-GROR | 20 (40 μL) | 200 μL |
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| NRP1-CUL2-20-GRGO | 20 (40 μL) | 200 μL |
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| NRP1-CUL2-20-GRGR | 20 (40 μL) | 200 μL |
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| NRP1-CUL2-20-GRAQ | 20 (40 μL) | 200 μL |
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| NRP1-CUL2-20-AQRE | 20 (40 μL) | 200 μL |
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| NRP1-CUL2-20-AQOR | 20 (40 μL) | 200 μL |
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| NRP1-CUL2-20-AQGO | 20 (40 μL) | 200 μL |
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| NRP1-CUL2-20-AQGR | 20 (40 μL) | 200 μL |
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| NRP1-CUL2-20-AQAQ | 20 (40 μL) | 200 μL |
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CUL2 Gene Summary
The Cullin 2 (CUL2) gene is located on chr10 :35297478-35379570 at 10p11.21.
Gene Name: Cullin 2
Chromosome: CHR10: 35297478 -35379570
Locus: 10p11.21
NRP1 Gene Summary
This gene encodes one of two neuropilins, which contain specific protein domains which allow them to participate in several different types of signaling pathways that control cell migration. Neuropilins contain a large N-terminal extracellular domain, made up of complement-binding, coagulation factor V/VIII, and meprin domains. These proteins also contains a short membrane-spanning domain and a small cytoplasmic domain. Neuropilins bind many ligands and various types of co-receptors; they affect cell survival, migration, and attraction. Some of the ligands and co-receptors bound by neuropilins are vascular endothelial growth factor (VEGF) and semaphorin family members. Several alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Oct 2011]
Gene Name: Neuropilin 1
Chromosome: CHR10: 33466418 -33623833
Locus: 10p11.22
Gene Diseases
The NRP1 CUL2 Fusion has been associated with the following diseases:
| Disease Name |
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| Brain Lower Grade Glioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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