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NSD1-RNF130 Fusion FISH Probe

The NSD1-RNF130 Fusion FISH Probe is used to confirm a fusion of the NSD1 and RNF130 genes. The fusion of the NSD1 and RNF130 genes has been associated with Brain Lower Grade Glioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
NSD1-RNF130-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
NSD1-RNF130-20-RERE 20 (40 μL) 200 μL
NSD1-RNF130-20-REOR 20 (40 μL) 200 μL
NSD1-RNF130-20-REGO 20 (40 μL) 200 μL
NSD1-RNF130-20-REGR 20 (40 μL) 200 μL
NSD1-RNF130-20-REAQ 20 (40 μL) 200 μL
NSD1-RNF130-20-ORRE 20 (40 μL) 200 μL
NSD1-RNF130-20-OROR 20 (40 μL) 200 μL
NSD1-RNF130-20-ORGO 20 (40 μL) 200 μL
NSD1-RNF130-20-ORAQ 20 (40 μL) 200 μL
NSD1-RNF130-20-GORE 20 (40 μL) 200 μL
NSD1-RNF130-20-GOOR 20 (40 μL) 200 μL
NSD1-RNF130-20-GOGO 20 (40 μL) 200 μL
NSD1-RNF130-20-GOGR 20 (40 μL) 200 μL
NSD1-RNF130-20-GOAQ 20 (40 μL) 200 μL
NSD1-RNF130-20-GRRE 20 (40 μL) 200 μL
NSD1-RNF130-20-GROR 20 (40 μL) 200 μL
NSD1-RNF130-20-GRGO 20 (40 μL) 200 μL
NSD1-RNF130-20-GRGR 20 (40 μL) 200 μL
NSD1-RNF130-20-GRAQ 20 (40 μL) 200 μL
NSD1-RNF130-20-AQRE 20 (40 μL) 200 μL
NSD1-RNF130-20-AQOR 20 (40 μL) 200 μL
NSD1-RNF130-20-AQGO 20 (40 μL) 200 μL
NSD1-RNF130-20-AQGR 20 (40 μL) 200 μL
NSD1-RNF130-20-AQAQ 20 (40 μL) 200 μL

RNF130 Gene Summary

The protein encoded by this gene contains a RING finger motif and is similar to g1, a Drosophila zinc-finger protein that is expressed in mesoderm and involved in embryonic development. The expression of the mouse counterpart was found to be upregulated in myeloblastic cells following IL3 deprivation, suggesting that this gene may regulate growth factor withdrawal-induced apoptosis of myeloid precursor cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

Gene Name: Ring Finger Protein 130

Chromosome: CHR5: 179382473 -179499109

Locus: 5q35.3

NSD1 Gene Summary

This gene encodes a protein containing a SET domain, 2 LXXLL motifs, 3 nuclear translocation signals (NLSs), 4 plant homeodomain (PHD) finger regions, and a proline-rich region. The encoded protein enhances androgen receptor (AR) transactivation, and this enhancement can be increased further in the presence of other androgen receptor associated coregulators. This protein may act as a nucleus-localized, basic transcriptional factor and also as a bifunctional transcriptional regulator. Mutations of this gene have been associated with Sotos syndrome and Weaver syndrome. One version of childhood acute myeloid leukemia is the result of a cryptic translocation with the breakpoints occurring within nuclear receptor-binding Su-var, enhancer of zeste, and trithorax domain protein 1 on chromosome 5 and nucleoporin, 98-kd on chromosome 11. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

Gene Name: Nuclear Receptor Binding SET Domain Protein 1

Chromosome: CHR5: 176560079 -176727214

Locus: 5q35.3

Gene Diseases

The NSD1 RNF130 Fusion has been associated with the following diseases:

Disease Name
Brain Lower Grade Glioma

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this probe.