NSMCE2-SNTB1 Fusion FISH Probe
The NSMCE2-SNTB1 Fusion FISH Probe is used to confirm a fusion of the NSMCE2 and SNTB1 genes. The fusion of the NSMCE2 and SNTB1 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| NSMCE2-SNTB1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| NSMCE2-SNTB1-20-RERE | 20 (40 μL) | 200 μL |
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| NSMCE2-SNTB1-20-REOR | 20 (40 μL) | 200 μL |
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| NSMCE2-SNTB1-20-REGO | 20 (40 μL) | 200 μL |
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| NSMCE2-SNTB1-20-REGR | 20 (40 μL) | 200 μL |
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| NSMCE2-SNTB1-20-REAQ | 20 (40 μL) | 200 μL |
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| NSMCE2-SNTB1-20-ORRE | 20 (40 μL) | 200 μL |
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| NSMCE2-SNTB1-20-OROR | 20 (40 μL) | 200 μL |
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| NSMCE2-SNTB1-20-ORGO | 20 (40 μL) | 200 μL |
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| NSMCE2-SNTB1-20-ORAQ | 20 (40 μL) | 200 μL |
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| NSMCE2-SNTB1-20-GORE | 20 (40 μL) | 200 μL |
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| NSMCE2-SNTB1-20-GOOR | 20 (40 μL) | 200 μL |
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| NSMCE2-SNTB1-20-GOGO | 20 (40 μL) | 200 μL |
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| NSMCE2-SNTB1-20-GOGR | 20 (40 μL) | 200 μL |
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| NSMCE2-SNTB1-20-GOAQ | 20 (40 μL) | 200 μL |
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| NSMCE2-SNTB1-20-GRRE | 20 (40 μL) | 200 μL |
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| NSMCE2-SNTB1-20-GROR | 20 (40 μL) | 200 μL |
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| NSMCE2-SNTB1-20-GRGO | 20 (40 μL) | 200 μL |
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| NSMCE2-SNTB1-20-GRGR | 20 (40 μL) | 200 μL |
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| NSMCE2-SNTB1-20-GRAQ | 20 (40 μL) | 200 μL |
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| NSMCE2-SNTB1-20-AQRE | 20 (40 μL) | 200 μL |
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| NSMCE2-SNTB1-20-AQOR | 20 (40 μL) | 200 μL |
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| NSMCE2-SNTB1-20-AQGO | 20 (40 μL) | 200 μL |
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| NSMCE2-SNTB1-20-AQGR | 20 (40 μL) | 200 μL |
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| NSMCE2-SNTB1-20-AQAQ | 20 (40 μL) | 200 μL |
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SNTB1 Gene Summary
Dystrophin is a large, rod-like cytoskeletal protein found at the inner surface of muscle fibers. Dystrophin is missing in Duchenne Muscular Dystrophy patients and is present in reduced amounts in Becker Muscular Dystrophy patients. The protein encoded by this gene is a peripheral membrane protein found associated with dystrophin and dystrophin-related proteins. This gene is a member of the syntrophin gene family, which contains at least two other structurally-related genes. [provided by RefSeq, Jul 2008]
Gene Name: Syntrophin Beta 1
Chromosome: CHR8: 121547984 -121824309
Locus: 8q24.12
NSMCE2 Gene Summary
This gene encodes a member of a family of E3 small ubiquitin-related modifier (SUMO) ligases that mediates the attachment of a SUMO protein to proteins involved in nuclear transport, transcription, chromosome segregation and DNA repair. The encoded protein is part of the structural maintenance of chromosomes (SMC) 5/6 complex which plays a key role genome maintenance, facilitating chromosome segregation and suppressing mitotic recombination. A knockout of the orthologous mouse gene is lethal prior to embryonic day 10.5. Naturally occurring mutations in this gene, that abolish the SUMO ligase activity, are associated with primordial dwarfism and extreme insulin resistance. [provided by RefSeq, Mar 2017]
Gene Name: NSE2/MMS21 Homolog, SMC5-SMC6 Complex SUMO Ligase
Chromosome: CHR8: 126104082 -126379367
Locus: 8q24.13
Gene Diseases
The NSMCE2 SNTB1 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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