NUMB-DNM2 Fusion FISH Probe
The NUMB-DNM2 Fusion FISH Probe is used to confirm a fusion of the NUMB and DNM2 genes. The fusion of the NUMB and DNM2 genes has been associated with Uterine Carcinosarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| NUMB-DNM2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| NUMB-DNM2-20-RERE | 20 (40 μL) | 200 μL |
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| NUMB-DNM2-20-REOR | 20 (40 μL) | 200 μL |
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| NUMB-DNM2-20-REGO | 20 (40 μL) | 200 μL |
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| NUMB-DNM2-20-REGR | 20 (40 μL) | 200 μL |
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| NUMB-DNM2-20-REAQ | 20 (40 μL) | 200 μL |
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| NUMB-DNM2-20-ORRE | 20 (40 μL) | 200 μL |
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| NUMB-DNM2-20-OROR | 20 (40 μL) | 200 μL |
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| NUMB-DNM2-20-ORGO | 20 (40 μL) | 200 μL |
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| NUMB-DNM2-20-ORAQ | 20 (40 μL) | 200 μL |
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| NUMB-DNM2-20-GORE | 20 (40 μL) | 200 μL |
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| NUMB-DNM2-20-GOOR | 20 (40 μL) | 200 μL |
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| NUMB-DNM2-20-GOGO | 20 (40 μL) | 200 μL |
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| NUMB-DNM2-20-GOGR | 20 (40 μL) | 200 μL |
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| NUMB-DNM2-20-GOAQ | 20 (40 μL) | 200 μL |
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| NUMB-DNM2-20-GRRE | 20 (40 μL) | 200 μL |
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| NUMB-DNM2-20-GROR | 20 (40 μL) | 200 μL |
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| NUMB-DNM2-20-GRGO | 20 (40 μL) | 200 μL |
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| NUMB-DNM2-20-GRGR | 20 (40 μL) | 200 μL |
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| NUMB-DNM2-20-GRAQ | 20 (40 μL) | 200 μL |
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| NUMB-DNM2-20-AQRE | 20 (40 μL) | 200 μL |
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| NUMB-DNM2-20-AQOR | 20 (40 μL) | 200 μL |
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| NUMB-DNM2-20-AQGO | 20 (40 μL) | 200 μL |
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| NUMB-DNM2-20-AQGR | 20 (40 μL) | 200 μL |
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| NUMB-DNM2-20-AQAQ | 20 (40 μL) | 200 μL |
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DNM2 Gene Summary
Dynamins represent one of the subfamilies of GTP-binding proteins. These proteins share considerable sequence similarity over the N-terminal portion of the molecule, which contains the GTPase domain. Dynamins are associated with microtubules. They have been implicated in cell processes such as endocytosis and cell motility, and in alterations of the membrane that accompany certain activities such as bone resorption by osteoclasts. Dynamins bind many proteins that bind actin and other cytoskeletal proteins. Dynamins can also self-assemble, a process that stimulates GTPase activity. Five alternatively spliced transcripts encoding different proteins have been described. Additional alternatively spliced transcripts may exist, but their full-length nature has not been determined. [provided by RefSeq, Jun 2010]
Gene Name: Dynamin 2
Chromosome: CHR19: 10828728 -10942586
Locus: 19p13.2
NUMB Gene Summary
The protein encoded by this gene plays a role in the determination of cell fates during development. The encoded protein, whose degradation is induced in a proteasome-dependent manner by MDM2, is a membrane-bound protein that has been shown to associate with EPS15, LNX1, and NOTCH1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
Gene Name: NUMB, Endocytic Adaptor Protein
Chromosome: CHR14: 73741917 -73925286
Locus: 14q24.2-q24.3
Gene Diseases
The NUMB DNM2 Fusion has been associated with the following diseases:
| Disease Name |
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| Uterine Carcinosarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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