OSTF1-SMARCA4 Fusion FISH Probe
The OSTF1-SMARCA4 Fusion FISH Probe is used to confirm a fusion of the OSTF1 and SMARCA4 genes. The fusion of the OSTF1 and SMARCA4 genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| OSTF1-SMARCA4-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| OSTF1-SMARCA4-20-RERE | 20 (40 μL) | 200 μL |
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| OSTF1-SMARCA4-20-REOR | 20 (40 μL) | 200 μL |
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| OSTF1-SMARCA4-20-REGO | 20 (40 μL) | 200 μL |
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| OSTF1-SMARCA4-20-REGR | 20 (40 μL) | 200 μL |
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| OSTF1-SMARCA4-20-REAQ | 20 (40 μL) | 200 μL |
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| OSTF1-SMARCA4-20-ORRE | 20 (40 μL) | 200 μL |
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| OSTF1-SMARCA4-20-OROR | 20 (40 μL) | 200 μL |
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| OSTF1-SMARCA4-20-ORGO | 20 (40 μL) | 200 μL |
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| OSTF1-SMARCA4-20-ORAQ | 20 (40 μL) | 200 μL |
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| OSTF1-SMARCA4-20-GORE | 20 (40 μL) | 200 μL |
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| OSTF1-SMARCA4-20-GOOR | 20 (40 μL) | 200 μL |
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| OSTF1-SMARCA4-20-GOGO | 20 (40 μL) | 200 μL |
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| OSTF1-SMARCA4-20-GOGR | 20 (40 μL) | 200 μL |
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| OSTF1-SMARCA4-20-GOAQ | 20 (40 μL) | 200 μL |
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| OSTF1-SMARCA4-20-GRRE | 20 (40 μL) | 200 μL |
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| OSTF1-SMARCA4-20-GROR | 20 (40 μL) | 200 μL |
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| OSTF1-SMARCA4-20-GRGO | 20 (40 μL) | 200 μL |
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| OSTF1-SMARCA4-20-GRGR | 20 (40 μL) | 200 μL |
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| OSTF1-SMARCA4-20-GRAQ | 20 (40 μL) | 200 μL |
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| OSTF1-SMARCA4-20-AQRE | 20 (40 μL) | 200 μL |
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| OSTF1-SMARCA4-20-AQOR | 20 (40 μL) | 200 μL |
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| OSTF1-SMARCA4-20-AQGO | 20 (40 μL) | 200 μL |
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| OSTF1-SMARCA4-20-AQGR | 20 (40 μL) | 200 μL |
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| OSTF1-SMARCA4-20-AQAQ | 20 (40 μL) | 200 μL |
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SMARCA4 Gene Summary
The protein encoded by this gene is a member of the SWI/SNF family of proteins and is similar to the brahma protein of Drosophila. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. In addition, this protein can bind BRCA1, as well as regulate the expression of the tumorigenic protein CD44. Mutations in this gene cause rhabdoid tumor predisposition syndrome type 2. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]
Gene Name: SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily A, Member 4
Chromosome: CHR19: 11071597 -11172958
Locus: 19p13.2
OSTF1 Gene Summary
Osteoclast-stimulating factor-1 is an intracellular protein produced by osteoclasts that indirectly induces osteoclast formation and bone resorption (Reddy et al., 1998 [PubMed 10092216]).[supplied by OMIM, Mar 2008]
Gene Name: Osteoclast Stimulating Factor 1
Chromosome: CHR9: 77703397 -77762114
Locus: 9q21.13
Gene Diseases
The OSTF1 SMARCA4 Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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