P4HB-CCT5 Fusion FISH Probe
The P4HB-CCT5 Fusion FISH Probe is used to confirm a fusion of the P4HB and CCT5 genes. The fusion of the P4HB and CCT5 genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| P4HB-CCT5-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| P4HB-CCT5-20-RERE | 20 (40 μL) | 200 μL |
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| P4HB-CCT5-20-REOR | 20 (40 μL) | 200 μL |
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| P4HB-CCT5-20-REGO | 20 (40 μL) | 200 μL |
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| P4HB-CCT5-20-REGR | 20 (40 μL) | 200 μL |
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| P4HB-CCT5-20-REAQ | 20 (40 μL) | 200 μL |
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| P4HB-CCT5-20-ORRE | 20 (40 μL) | 200 μL |
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| P4HB-CCT5-20-OROR | 20 (40 μL) | 200 μL |
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| P4HB-CCT5-20-ORGO | 20 (40 μL) | 200 μL |
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| P4HB-CCT5-20-ORAQ | 20 (40 μL) | 200 μL |
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| P4HB-CCT5-20-GORE | 20 (40 μL) | 200 μL |
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| P4HB-CCT5-20-GOOR | 20 (40 μL) | 200 μL |
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| P4HB-CCT5-20-GOGO | 20 (40 μL) | 200 μL |
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| P4HB-CCT5-20-GOGR | 20 (40 μL) | 200 μL |
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| P4HB-CCT5-20-GOAQ | 20 (40 μL) | 200 μL |
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| P4HB-CCT5-20-GRRE | 20 (40 μL) | 200 μL |
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| P4HB-CCT5-20-GROR | 20 (40 μL) | 200 μL |
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| P4HB-CCT5-20-GRGO | 20 (40 μL) | 200 μL |
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| P4HB-CCT5-20-GRGR | 20 (40 μL) | 200 μL |
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| P4HB-CCT5-20-GRAQ | 20 (40 μL) | 200 μL |
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| P4HB-CCT5-20-AQRE | 20 (40 μL) | 200 μL |
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| P4HB-CCT5-20-AQOR | 20 (40 μL) | 200 μL |
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| P4HB-CCT5-20-AQGO | 20 (40 μL) | 200 μL |
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| P4HB-CCT5-20-AQGR | 20 (40 μL) | 200 μL |
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| P4HB-CCT5-20-AQAQ | 20 (40 μL) | 200 μL |
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P4HB Gene Summary
This gene encodes the beta subunit of prolyl 4-hydroxylase, a highly abundant multifunctional enzyme that belongs to the protein disulfide isomerase family. When present as a tetramer consisting of two alpha and two beta subunits, this enzyme is involved in hydroxylation of prolyl residues in preprocollagen. This enzyme is also a disulfide isomerase containing two thioredoxin domains that catalyze the formation, breakage and rearrangement of disulfide bonds. Other known functions include its ability to act as a chaperone that inhibits aggregation of misfolded proteins in a concentration-dependent manner, its ability to bind thyroid hormone, its role in both the influx and efflux of S-nitrosothiol-bound nitric oxide, and its function as a subunit of the microsomal triglyceride transfer protein complex. [provided by RefSeq, Jul 2008]
Gene Name: Prolyl 4-hydroxylase Subunit Beta
Chromosome: CHR17: 79801033 -79818544
Locus: 17q25.3
CCT5 Gene Summary
The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Mutations in this gene cause hereditary sensory and autonomic neuropathy with spastic paraplegia (HSNSP). Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 5 and 13. [provided by RefSeq, Apr 2015]
Gene Name: Chaperonin Containing TCP1 Subunit 5
Chromosome: CHR5: 10250281 -10266501
Locus: 5p15.2
Gene Diseases
The P4HB CCT5 Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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