P4HB-ERBB3 Fusion FISH Probe
The P4HB-ERBB3 Fusion FISH Probe is used to confirm a fusion of the P4HB and ERBB3 genes. The fusion of the P4HB and ERBB3 genes has been associated with Adrenocortical Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| P4HB-ERBB3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| P4HB-ERBB3-20-RERE | 20 (40 μL) | 200 μL |
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| P4HB-ERBB3-20-REOR | 20 (40 μL) | 200 μL |
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| P4HB-ERBB3-20-REGO | 20 (40 μL) | 200 μL |
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| P4HB-ERBB3-20-REGR | 20 (40 μL) | 200 μL |
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| P4HB-ERBB3-20-REAQ | 20 (40 μL) | 200 μL |
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| P4HB-ERBB3-20-ORRE | 20 (40 μL) | 200 μL |
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| P4HB-ERBB3-20-OROR | 20 (40 μL) | 200 μL |
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| P4HB-ERBB3-20-ORGO | 20 (40 μL) | 200 μL |
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| P4HB-ERBB3-20-ORAQ | 20 (40 μL) | 200 μL |
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| P4HB-ERBB3-20-GORE | 20 (40 μL) | 200 μL |
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| P4HB-ERBB3-20-GOOR | 20 (40 μL) | 200 μL |
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| P4HB-ERBB3-20-GOGO | 20 (40 μL) | 200 μL |
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| P4HB-ERBB3-20-GOGR | 20 (40 μL) | 200 μL |
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| P4HB-ERBB3-20-GOAQ | 20 (40 μL) | 200 μL |
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| P4HB-ERBB3-20-GRRE | 20 (40 μL) | 200 μL |
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| P4HB-ERBB3-20-GROR | 20 (40 μL) | 200 μL |
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| P4HB-ERBB3-20-GRGO | 20 (40 μL) | 200 μL |
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| P4HB-ERBB3-20-GRGR | 20 (40 μL) | 200 μL |
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| P4HB-ERBB3-20-GRAQ | 20 (40 μL) | 200 μL |
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| P4HB-ERBB3-20-AQRE | 20 (40 μL) | 200 μL |
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| P4HB-ERBB3-20-AQOR | 20 (40 μL) | 200 μL |
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| P4HB-ERBB3-20-AQGO | 20 (40 μL) | 200 μL |
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| P4HB-ERBB3-20-AQGR | 20 (40 μL) | 200 μL |
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| P4HB-ERBB3-20-AQAQ | 20 (40 μL) | 200 μL |
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ERBB3 Gene Summary
This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized. [provided by RefSeq, Jul 2008]
Gene Name: Erb-b2 Receptor Tyrosine Kinase 3
Chromosome: CHR12: 56473808 -56497291
Locus: 12q13.2
P4HB Gene Summary
This gene encodes the beta subunit of prolyl 4-hydroxylase, a highly abundant multifunctional enzyme that belongs to the protein disulfide isomerase family. When present as a tetramer consisting of two alpha and two beta subunits, this enzyme is involved in hydroxylation of prolyl residues in preprocollagen. This enzyme is also a disulfide isomerase containing two thioredoxin domains that catalyze the formation, breakage and rearrangement of disulfide bonds. Other known functions include its ability to act as a chaperone that inhibits aggregation of misfolded proteins in a concentration-dependent manner, its ability to bind thyroid hormone, its role in both the influx and efflux of S-nitrosothiol-bound nitric oxide, and its function as a subunit of the microsomal triglyceride transfer protein complex. [provided by RefSeq, Jul 2008]
Gene Name: Prolyl 4-hydroxylase Subunit Beta
Chromosome: CHR17: 79801033 -79818544
Locus: 17q25.3
Gene Diseases
The P4HB ERBB3 Fusion has been associated with the following diseases:
| Disease Name |
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| Adrenocortical Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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