PARN-PLA2G10 Fusion FISH Probe
The PARN-PLA2G10 Fusion FISH Probe is used to confirm a fusion of the PARN and PLA2G10 genes. The fusion of the PARN and PLA2G10 genes has been associated with Brain Lower Grade Glioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PARN-PLA2G10-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PARN-PLA2G10-20-RERE | 20 (40 μL) | 200 μL |
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| PARN-PLA2G10-20-REOR | 20 (40 μL) | 200 μL |
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| PARN-PLA2G10-20-REGO | 20 (40 μL) | 200 μL |
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| PARN-PLA2G10-20-REGR | 20 (40 μL) | 200 μL |
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| PARN-PLA2G10-20-REAQ | 20 (40 μL) | 200 μL |
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| PARN-PLA2G10-20-ORRE | 20 (40 μL) | 200 μL |
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| PARN-PLA2G10-20-OROR | 20 (40 μL) | 200 μL |
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| PARN-PLA2G10-20-ORGO | 20 (40 μL) | 200 μL |
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| PARN-PLA2G10-20-ORAQ | 20 (40 μL) | 200 μL |
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| PARN-PLA2G10-20-GORE | 20 (40 μL) | 200 μL |
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| PARN-PLA2G10-20-GOOR | 20 (40 μL) | 200 μL |
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| PARN-PLA2G10-20-GOGO | 20 (40 μL) | 200 μL |
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| PARN-PLA2G10-20-GOGR | 20 (40 μL) | 200 μL |
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| PARN-PLA2G10-20-GOAQ | 20 (40 μL) | 200 μL |
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| PARN-PLA2G10-20-GRRE | 20 (40 μL) | 200 μL |
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| PARN-PLA2G10-20-GROR | 20 (40 μL) | 200 μL |
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| PARN-PLA2G10-20-GRGO | 20 (40 μL) | 200 μL |
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| PARN-PLA2G10-20-GRGR | 20 (40 μL) | 200 μL |
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| PARN-PLA2G10-20-GRAQ | 20 (40 μL) | 200 μL |
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| PARN-PLA2G10-20-AQRE | 20 (40 μL) | 200 μL |
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| PARN-PLA2G10-20-AQOR | 20 (40 μL) | 200 μL |
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| PARN-PLA2G10-20-AQGO | 20 (40 μL) | 200 μL |
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| PARN-PLA2G10-20-AQGR | 20 (40 μL) | 200 μL |
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| PARN-PLA2G10-20-AQAQ | 20 (40 μL) | 200 μL |
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PARN Gene Summary
The protein encoded by this gene is a 3'-exoribonuclease, with similarity to the RNase D family of 3'-exonucleases. It prefers poly(A) as the substrate, hence, efficiently degrades poly(A) tails of mRNAs. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs. This protein is also involved in silencing of certain maternal mRNAs during oocyte maturation and early embryonic development, as well as in nonsense-mediated decay (NMD) of mRNAs that contain premature stop codons. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
Gene Name: Poly(A)-specific Ribonuclease
Chromosome: CHR16: 14529556 -14724128
Locus: 16p13.12
PLA2G10 Gene Summary
This gene encodes a member of the phospholipase A2 family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature enzyme. This calcium-dependent enzyme hydrolyzes glycerophospholipids to produce free fatty acids and lysophospholipids. In one example, this enzyme catalyzes the release of arachidonic acid from cell membrane phospholipids, thus playing a role in the production of various inflammatory lipid mediators, such as prostaglandins. The encoded protein may promote the survival of breast cancer cells through its role in lipid metabolism. [provided by RefSeq, Nov 2015]
Gene Name: Phospholipase A2 Group X
Chromosome: CHR16: 14766404 -14788526
Locus: 16p13.12
Gene Diseases
The PARN PLA2G10 Fusion has been associated with the following diseases:
| Disease Name |
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| Brain Lower Grade Glioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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