PARN-SMG1 Fusion FISH Probe
The PARN-SMG1 Fusion FISH Probe is used to confirm a fusion of the PARN and SMG1 genes. The fusion of the PARN and SMG1 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PARN-SMG1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PARN-SMG1-20-RERE | 20 (40 μL) | 200 μL |
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| PARN-SMG1-20-REOR | 20 (40 μL) | 200 μL |
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| PARN-SMG1-20-REGO | 20 (40 μL) | 200 μL |
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| PARN-SMG1-20-REGR | 20 (40 μL) | 200 μL |
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| PARN-SMG1-20-REAQ | 20 (40 μL) | 200 μL |
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| PARN-SMG1-20-ORRE | 20 (40 μL) | 200 μL |
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| PARN-SMG1-20-OROR | 20 (40 μL) | 200 μL |
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| PARN-SMG1-20-ORGO | 20 (40 μL) | 200 μL |
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| PARN-SMG1-20-ORAQ | 20 (40 μL) | 200 μL |
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| PARN-SMG1-20-GORE | 20 (40 μL) | 200 μL |
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| PARN-SMG1-20-GOOR | 20 (40 μL) | 200 μL |
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| PARN-SMG1-20-GOGO | 20 (40 μL) | 200 μL |
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| PARN-SMG1-20-GOGR | 20 (40 μL) | 200 μL |
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| PARN-SMG1-20-GOAQ | 20 (40 μL) | 200 μL |
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| PARN-SMG1-20-GRRE | 20 (40 μL) | 200 μL |
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| PARN-SMG1-20-GROR | 20 (40 μL) | 200 μL |
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| PARN-SMG1-20-GRGO | 20 (40 μL) | 200 μL |
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| PARN-SMG1-20-GRGR | 20 (40 μL) | 200 μL |
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| PARN-SMG1-20-GRAQ | 20 (40 μL) | 200 μL |
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| PARN-SMG1-20-AQRE | 20 (40 μL) | 200 μL |
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| PARN-SMG1-20-AQOR | 20 (40 μL) | 200 μL |
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| PARN-SMG1-20-AQGO | 20 (40 μL) | 200 μL |
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| PARN-SMG1-20-AQGR | 20 (40 μL) | 200 μL |
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| PARN-SMG1-20-AQAQ | 20 (40 μL) | 200 μL |
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PARN Gene Summary
The protein encoded by this gene is a 3'-exoribonuclease, with similarity to the RNase D family of 3'-exonucleases. It prefers poly(A) as the substrate, hence, efficiently degrades poly(A) tails of mRNAs. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs. This protein is also involved in silencing of certain maternal mRNAs during oocyte maturation and early embryonic development, as well as in nonsense-mediated decay (NMD) of mRNAs that contain premature stop codons. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
Gene Name: Poly(A)-specific Ribonuclease
Chromosome: CHR16: 14529556 -14724128
Locus: 16p13.12
SMG1 Gene Summary
This gene encodes a protein involved in nonsense-mediated mRNA decay (NMD) as part of the mRNA surveillance complex. The protein has kinase activity and is thought to function in NMD by phosphorylating the regulator of nonsense transcripts 1 protein. Alternatively spliced transcript variants have been described, but their full-length nature has yet to be determined. [provided by RefSeq, Mar 2013]
Gene Name: SMG1, Nonsense Mediated MRNA Decay Associated PI3K Related Kinase
Chromosome: CHR16: 18816174 -18937726
Locus: 16p12.3
Gene Diseases
The PARN SMG1 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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