PATZ1-PKIB Fusion FISH Probe
The PATZ1-PKIB Fusion FISH Probe is used to confirm a fusion of the PATZ1 and PKIB genes. The fusion of the PATZ1 and PKIB genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PATZ1-PKIB-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PATZ1-PKIB-20-RERE | 20 (40 μL) | 200 μL |
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| PATZ1-PKIB-20-REOR | 20 (40 μL) | 200 μL |
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| PATZ1-PKIB-20-REGO | 20 (40 μL) | 200 μL |
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| PATZ1-PKIB-20-REGR | 20 (40 μL) | 200 μL |
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| PATZ1-PKIB-20-REAQ | 20 (40 μL) | 200 μL |
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| PATZ1-PKIB-20-ORRE | 20 (40 μL) | 200 μL |
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| PATZ1-PKIB-20-OROR | 20 (40 μL) | 200 μL |
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| PATZ1-PKIB-20-ORGO | 20 (40 μL) | 200 μL |
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| PATZ1-PKIB-20-ORAQ | 20 (40 μL) | 200 μL |
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| PATZ1-PKIB-20-GORE | 20 (40 μL) | 200 μL |
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| PATZ1-PKIB-20-GOOR | 20 (40 μL) | 200 μL |
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| PATZ1-PKIB-20-GOGO | 20 (40 μL) | 200 μL |
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| PATZ1-PKIB-20-GOGR | 20 (40 μL) | 200 μL |
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| PATZ1-PKIB-20-GOAQ | 20 (40 μL) | 200 μL |
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| PATZ1-PKIB-20-GRRE | 20 (40 μL) | 200 μL |
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| PATZ1-PKIB-20-GROR | 20 (40 μL) | 200 μL |
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| PATZ1-PKIB-20-GRGO | 20 (40 μL) | 200 μL |
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| PATZ1-PKIB-20-GRGR | 20 (40 μL) | 200 μL |
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| PATZ1-PKIB-20-GRAQ | 20 (40 μL) | 200 μL |
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| PATZ1-PKIB-20-AQRE | 20 (40 μL) | 200 μL |
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| PATZ1-PKIB-20-AQOR | 20 (40 μL) | 200 μL |
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| PATZ1-PKIB-20-AQGO | 20 (40 μL) | 200 μL |
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| PATZ1-PKIB-20-AQGR | 20 (40 μL) | 200 μL |
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| PATZ1-PKIB-20-AQAQ | 20 (40 μL) | 200 μL |
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PKIB Gene Summary
This gene encodes a member of the cAMP-dependent protein kinase inhibitor family. The encoded protein may play a role in the protein kinase A (PKA) pathway by interacting with the catalytic subunit of PKA, and overexpression of this gene may play a role in prostate cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]
Gene Name: CAMP-dependent Protein Kinase Inhibitor Beta
Chromosome: CHR6: 122793061 -123047518
Locus: 6q22.31
PATZ1 Gene Summary
The protein encoded by this gene contains an A-T hook DNA binding motif which usually binds to other DNA binding structures to play an important role in chromatin modeling and transcription regulation. Its Poz domain is thought to function as a site for protein-protein interaction and is required for transcriptional repression, and the zinc-fingers comprise the DNA binding domain. Since the encoded protein has typical features of a transcription factor, it is postulated to be a repressor of gene expression. In small round cell sarcoma, this gene is fused to EWS by a small inversion of 22q, then the hybrid is thought to be translocated (t(1;22)(p36.1;q12). The rearrangement of chromosome 22 involves intron 8 of EWS and exon 1 of this gene creating a chimeric sequence containing the transactivation domain of EWS fused to zinc finger domain of this protein. This is a distinct example of an intra-chromosomal rearrangement of chromosome 22. Four alternatively spliced transcript variants are described for this gene. [provided by RefSeq, Jul 2008]
Gene Name: POZ/BTB And AT Hook Containing Zinc Finger 1
Chromosome: CHR22: 31721789 -31742249
Locus: 22q12.2
Gene Diseases
The PATZ1 PKIB Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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