PAWR-PTPRR Fusion FISH Probe
The PAWR-PTPRR Fusion FISH Probe is used to confirm a fusion of the PAWR and PTPRR genes. The fusion of the PAWR and PTPRR genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PAWR-PTPRR-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PAWR-PTPRR-20-RERE | 20 (40 μL) | 200 μL |
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| PAWR-PTPRR-20-REOR | 20 (40 μL) | 200 μL |
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| PAWR-PTPRR-20-REGO | 20 (40 μL) | 200 μL |
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| PAWR-PTPRR-20-REGR | 20 (40 μL) | 200 μL |
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| PAWR-PTPRR-20-REAQ | 20 (40 μL) | 200 μL |
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| PAWR-PTPRR-20-ORRE | 20 (40 μL) | 200 μL |
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| PAWR-PTPRR-20-OROR | 20 (40 μL) | 200 μL |
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| PAWR-PTPRR-20-ORGO | 20 (40 μL) | 200 μL |
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| PAWR-PTPRR-20-ORAQ | 20 (40 μL) | 200 μL |
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| PAWR-PTPRR-20-GORE | 20 (40 μL) | 200 μL |
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| PAWR-PTPRR-20-GOOR | 20 (40 μL) | 200 μL |
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| PAWR-PTPRR-20-GOGO | 20 (40 μL) | 200 μL |
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| PAWR-PTPRR-20-GOGR | 20 (40 μL) | 200 μL |
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| PAWR-PTPRR-20-GOAQ | 20 (40 μL) | 200 μL |
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| PAWR-PTPRR-20-GRRE | 20 (40 μL) | 200 μL |
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| PAWR-PTPRR-20-GROR | 20 (40 μL) | 200 μL |
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| PAWR-PTPRR-20-GRGO | 20 (40 μL) | 200 μL |
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| PAWR-PTPRR-20-GRGR | 20 (40 μL) | 200 μL |
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| PAWR-PTPRR-20-GRAQ | 20 (40 μL) | 200 μL |
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| PAWR-PTPRR-20-AQRE | 20 (40 μL) | 200 μL |
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| PAWR-PTPRR-20-AQOR | 20 (40 μL) | 200 μL |
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| PAWR-PTPRR-20-AQGO | 20 (40 μL) | 200 μL |
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| PAWR-PTPRR-20-AQGR | 20 (40 μL) | 200 μL |
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| PAWR-PTPRR-20-AQAQ | 20 (40 μL) | 200 μL |
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PAWR Gene Summary
This gene encodes a tumor suppressor protein that selectively induces apoptosis in cancer cells through intracellular and extracellular mechanisms. The intracellular mechanism involves the inhibition of pro-survival pathways and the activation of Fas-mediated apoptosis, while the extracellular mechanism involves the binding of a secreted form of this protein to glucose regulated protein 78 (GRP78) on the cell surface, which leads to activation of the extrinsic apoptotic pathway. This gene is located on the unstable human chromosomal 12q21 region and is often deleted or mutated different tumors. The encoded protein also plays an important role in the progression of age-related diseases. [provided by RefSeq, Aug 2017]
Gene Name: Pro-apoptotic WT1 Regulator
Chromosome: CHR12: 79985744 -80084790
Locus: 12q21.2
PTPRR Gene Summary
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single intracellular catalytic domain, and thus represents a receptor-type PTP. Silencing of this gene has been associated with colorectal cancer. Multiple transcript variants encoding different isoforms have been found for this gene. This gene shares a symbol (PTPRQ) with another gene, protein tyrosine phosphatase, receptor type, Q (GeneID 374462), which is also located on chromosome 12. [provided by RefSeq, May 2011]
Gene Name: Protein Tyrosine Phosphatase, Receptor Type R
Chromosome: CHR12: 71031852 -71314584
Locus: 12q15
Gene Diseases
The PAWR PTPRR Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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