PAX8-NFE2L2 Fusion FISH Probe
The PAX8-NFE2L2 Fusion FISH Probe is used to confirm a fusion of the PAX8 and NFE2L2 genes. The fusion of the PAX8 and NFE2L2 genes has been associated with Thyroid Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PAX8-NFE2L2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PAX8-NFE2L2-20-RERE | 20 (40 μL) | 200 μL |
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| PAX8-NFE2L2-20-REOR | 20 (40 μL) | 200 μL |
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| PAX8-NFE2L2-20-REGO | 20 (40 μL) | 200 μL |
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| PAX8-NFE2L2-20-REGR | 20 (40 μL) | 200 μL |
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| PAX8-NFE2L2-20-REAQ | 20 (40 μL) | 200 μL |
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| PAX8-NFE2L2-20-ORRE | 20 (40 μL) | 200 μL |
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| PAX8-NFE2L2-20-OROR | 20 (40 μL) | 200 μL |
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| PAX8-NFE2L2-20-ORGO | 20 (40 μL) | 200 μL |
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| PAX8-NFE2L2-20-ORAQ | 20 (40 μL) | 200 μL |
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| PAX8-NFE2L2-20-GORE | 20 (40 μL) | 200 μL |
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| PAX8-NFE2L2-20-GOOR | 20 (40 μL) | 200 μL |
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| PAX8-NFE2L2-20-GOGO | 20 (40 μL) | 200 μL |
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| PAX8-NFE2L2-20-GOGR | 20 (40 μL) | 200 μL |
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| PAX8-NFE2L2-20-GOAQ | 20 (40 μL) | 200 μL |
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| PAX8-NFE2L2-20-GRRE | 20 (40 μL) | 200 μL |
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| PAX8-NFE2L2-20-GROR | 20 (40 μL) | 200 μL |
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| PAX8-NFE2L2-20-GRGO | 20 (40 μL) | 200 μL |
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| PAX8-NFE2L2-20-GRGR | 20 (40 μL) | 200 μL |
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| PAX8-NFE2L2-20-GRAQ | 20 (40 μL) | 200 μL |
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| PAX8-NFE2L2-20-AQRE | 20 (40 μL) | 200 μL |
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| PAX8-NFE2L2-20-AQOR | 20 (40 μL) | 200 μL |
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| PAX8-NFE2L2-20-AQGO | 20 (40 μL) | 200 μL |
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| PAX8-NFE2L2-20-AQGR | 20 (40 μL) | 200 μL |
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| PAX8-NFE2L2-20-AQAQ | 20 (40 μL) | 200 μL |
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NFE2L2 Gene Summary
This gene encodes a transcription factor which is a member of a small family of basic leucine zipper (bZIP) proteins. The encoded transcription factor regulates genes which contain antioxidant response elements (ARE) in their promoters; many of these genes encode proteins involved in response to injury and inflammation which includes the production of free radicals. Multiple transcript variants encoding different isoforms have been characterized for this gene. [provided by RefSeq, Sep 2015]
Gene Name: Nuclear Factor, Erythroid 2 Like 2
Chromosome: CHR2: 178095032 -178129859
Locus: 2q31.2
PAX8 Gene Summary
This gene encodes a member of the paired box (PAX) family of transcription factors. Members of this gene family typically encode proteins that contain a paired box domain, an octapeptide, and a paired-type homeodomain. This nuclear protein is involved in thyroid follicular cell development and expression of thyroid-specific genes. Mutations in this gene have been associated with thyroid dysgenesis, thyroid follicular carcinomas and atypical follicular thyroid adenomas. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Mar 2010]
Gene Name: Paired Box 8
Chromosome: CHR2: 113973573 -114036498
Locus: 2q13
Gene Diseases
The PAX8 NFE2L2 Fusion has been associated with the following diseases:
| Disease Name |
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| Thyroid Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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