PBRM1-FBXW12 Fusion FISH Probe
The PBRM1-FBXW12 Fusion FISH Probe is used to confirm a fusion of the PBRM1 and FBXW12 genes. The fusion of the PBRM1 and FBXW12 genes has been associated with Mesothelioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PBRM1-FBXW12-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PBRM1-FBXW12-20-RERE | 20 (40 μL) | 200 μL |
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| PBRM1-FBXW12-20-REOR | 20 (40 μL) | 200 μL |
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| PBRM1-FBXW12-20-REGO | 20 (40 μL) | 200 μL |
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| PBRM1-FBXW12-20-REGR | 20 (40 μL) | 200 μL |
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| PBRM1-FBXW12-20-REAQ | 20 (40 μL) | 200 μL |
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| PBRM1-FBXW12-20-ORRE | 20 (40 μL) | 200 μL |
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| PBRM1-FBXW12-20-OROR | 20 (40 μL) | 200 μL |
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| PBRM1-FBXW12-20-ORGO | 20 (40 μL) | 200 μL |
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| PBRM1-FBXW12-20-ORAQ | 20 (40 μL) | 200 μL |
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| PBRM1-FBXW12-20-GORE | 20 (40 μL) | 200 μL |
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| PBRM1-FBXW12-20-GOOR | 20 (40 μL) | 200 μL |
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| PBRM1-FBXW12-20-GOGO | 20 (40 μL) | 200 μL |
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| PBRM1-FBXW12-20-GOGR | 20 (40 μL) | 200 μL |
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| PBRM1-FBXW12-20-GOAQ | 20 (40 μL) | 200 μL |
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| PBRM1-FBXW12-20-GRRE | 20 (40 μL) | 200 μL |
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| PBRM1-FBXW12-20-GROR | 20 (40 μL) | 200 μL |
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| PBRM1-FBXW12-20-GRGO | 20 (40 μL) | 200 μL |
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| PBRM1-FBXW12-20-GRGR | 20 (40 μL) | 200 μL |
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| PBRM1-FBXW12-20-GRAQ | 20 (40 μL) | 200 μL |
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| PBRM1-FBXW12-20-AQRE | 20 (40 μL) | 200 μL |
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| PBRM1-FBXW12-20-AQOR | 20 (40 μL) | 200 μL |
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| PBRM1-FBXW12-20-AQGO | 20 (40 μL) | 200 μL |
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| PBRM1-FBXW12-20-AQGR | 20 (40 μL) | 200 μL |
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| PBRM1-FBXW12-20-AQAQ | 20 (40 μL) | 200 μL |
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PBRM1 Gene Summary
This locus encodes a subunit of ATP-dependent chromatin-remodeling complexes. The encoded protein has been identified as in integral component of complexes necessary for ligand-dependent transcriptional activation by nuclear hormone receptors. Mutations at this locus have been associated with primary clear cell renal cell carcinoma. [provided by RefSeq, Feb 2012]
Gene Name: Polybromo 1
Chromosome: CHR3: 52579367 -52719866
Locus: 3p21.1
FBXW12 Gene Summary
Members of the F-box protein family, such as FBXW12, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603034), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]
Gene Name: F-box And WD Repeat Domain Containing 12
Chromosome: CHR3: 48413708 -48436190
Locus: 3p21.31
Gene Diseases
The PBRM1 FBXW12 Fusion has been associated with the following diseases:
| Disease Name |
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| Mesothelioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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