PBRM1-NEK4 Fusion FISH Probe
The PBRM1-NEK4 Fusion FISH Probe is used to confirm a fusion of the PBRM1 and NEK4 genes. The fusion of the PBRM1 and NEK4 genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PBRM1-NEK4-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PBRM1-NEK4-20-RERE | 20 (40 μL) | 200 μL |
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| PBRM1-NEK4-20-REOR | 20 (40 μL) | 200 μL |
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| PBRM1-NEK4-20-REGO | 20 (40 μL) | 200 μL |
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| PBRM1-NEK4-20-REGR | 20 (40 μL) | 200 μL |
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| PBRM1-NEK4-20-REAQ | 20 (40 μL) | 200 μL |
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| PBRM1-NEK4-20-ORRE | 20 (40 μL) | 200 μL |
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| PBRM1-NEK4-20-OROR | 20 (40 μL) | 200 μL |
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| PBRM1-NEK4-20-ORGO | 20 (40 μL) | 200 μL |
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| PBRM1-NEK4-20-ORAQ | 20 (40 μL) | 200 μL |
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| PBRM1-NEK4-20-GORE | 20 (40 μL) | 200 μL |
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| PBRM1-NEK4-20-GOOR | 20 (40 μL) | 200 μL |
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| PBRM1-NEK4-20-GOGO | 20 (40 μL) | 200 μL |
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| PBRM1-NEK4-20-GOGR | 20 (40 μL) | 200 μL |
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| PBRM1-NEK4-20-GOAQ | 20 (40 μL) | 200 μL |
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| PBRM1-NEK4-20-GRRE | 20 (40 μL) | 200 μL |
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| PBRM1-NEK4-20-GROR | 20 (40 μL) | 200 μL |
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| PBRM1-NEK4-20-GRGO | 20 (40 μL) | 200 μL |
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| PBRM1-NEK4-20-GRGR | 20 (40 μL) | 200 μL |
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| PBRM1-NEK4-20-GRAQ | 20 (40 μL) | 200 μL |
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| PBRM1-NEK4-20-AQRE | 20 (40 μL) | 200 μL |
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| PBRM1-NEK4-20-AQOR | 20 (40 μL) | 200 μL |
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| PBRM1-NEK4-20-AQGO | 20 (40 μL) | 200 μL |
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| PBRM1-NEK4-20-AQGR | 20 (40 μL) | 200 μL |
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| PBRM1-NEK4-20-AQAQ | 20 (40 μL) | 200 μL |
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NEK4 Gene Summary
The protein encoded by this gene is a serine/threonine protein kinase required for normal entry into replicative senescence. The encoded protein also is involved in cell cycle arrest in response to double-stranded DNA damage. Finally, this protein plays a role in maintaining cilium integrity, and defects in this gene have been associated with ciliopathies. [provided by RefSeq, Jan 2017]
Gene Name: NIMA Related Kinase 4
Chromosome: CHR3: 52744795 -52804965
Locus: 3p21.1
PBRM1 Gene Summary
This locus encodes a subunit of ATP-dependent chromatin-remodeling complexes. The encoded protein has been identified as in integral component of complexes necessary for ligand-dependent transcriptional activation by nuclear hormone receptors. Mutations at this locus have been associated with primary clear cell renal cell carcinoma. [provided by RefSeq, Feb 2012]
Gene Name: Polybromo 1
Chromosome: CHR3: 52579367 -52719866
Locus: 3p21.1
Gene Diseases
The PBRM1 NEK4 Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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