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PBX1-RFWD2 Fusion FISH Probe

The PBX1-RFWD2 Fusion FISH Probe is used to confirm a fusion of the PBX1 and RFWD2 genes. The fusion of the PBX1 and RFWD2 genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
PBX1-RFWD2-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
PBX1-RFWD2-20-RERE 20 (40 μL) 200 μL
PBX1-RFWD2-20-REOR 20 (40 μL) 200 μL
PBX1-RFWD2-20-REGO 20 (40 μL) 200 μL
PBX1-RFWD2-20-REGR 20 (40 μL) 200 μL
PBX1-RFWD2-20-REAQ 20 (40 μL) 200 μL
PBX1-RFWD2-20-ORRE 20 (40 μL) 200 μL
PBX1-RFWD2-20-OROR 20 (40 μL) 200 μL
PBX1-RFWD2-20-ORGO 20 (40 μL) 200 μL
PBX1-RFWD2-20-ORAQ 20 (40 μL) 200 μL
PBX1-RFWD2-20-GORE 20 (40 μL) 200 μL
PBX1-RFWD2-20-GOOR 20 (40 μL) 200 μL
PBX1-RFWD2-20-GOGO 20 (40 μL) 200 μL
PBX1-RFWD2-20-GOGR 20 (40 μL) 200 μL
PBX1-RFWD2-20-GOAQ 20 (40 μL) 200 μL
PBX1-RFWD2-20-GRRE 20 (40 μL) 200 μL
PBX1-RFWD2-20-GROR 20 (40 μL) 200 μL
PBX1-RFWD2-20-GRGO 20 (40 μL) 200 μL
PBX1-RFWD2-20-GRGR 20 (40 μL) 200 μL
PBX1-RFWD2-20-GRAQ 20 (40 μL) 200 μL
PBX1-RFWD2-20-AQRE 20 (40 μL) 200 μL
PBX1-RFWD2-20-AQOR 20 (40 μL) 200 μL
PBX1-RFWD2-20-AQGO 20 (40 μL) 200 μL
PBX1-RFWD2-20-AQGR 20 (40 μL) 200 μL
PBX1-RFWD2-20-AQAQ 20 (40 μL) 200 μL

PBX1 Gene Summary

This gene encodes a nuclear protein that belongs to the PBX homeobox family of transcriptional factors. Studies in mice suggest that this gene may be involved in the regulation of osteogenesis and required for skeletal patterning and programming. A chromosomal translocation, t(1;19) involving this gene and TCF3/E2A gene, is associated with pre-B-cell acute lymphoblastic leukemia. The resulting fusion protein, in which the DNA binding domain of E2A is replaced by the DNA binding domain of this protein, transforms cells by constitutively activating transcription of genes regulated by the PBX protein family. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2017]

Gene Name: PBX Homeobox 1

Chromosome: CHR1: 164528596 -164821060

Locus: 1q23.3

RFWD2 Gene Summary

The Ring Finger And WD Repeat Domain 2 (RFWD2) gene is located on chr1 :175913966-176176370 at 1q25.1-q25.2.

Gene Name: Ring Finger And WD Repeat Domain 2

Chromosome: CHR1: 175913966 -176176370

Locus: 1q25.1-q25.2

Gene Diseases

The PBX1 RFWD2 Fusion has been associated with the following diseases:

Disease Name
Sarcoma

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this probe.